EBI3 anticorps (AA 366-466)

N° du produit ABIN7874371

Cet anticorps anti-EBI3 Monoclonal Souris (Clone EBI3-8902) (ABIN7874371) détecte spécifiquement EBI3 dans ELISA et IHC (p). L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour EBI3 anticorps (AA 366-466) (ABIN7874371)

Antigène: EBI3 (IL-27b) (Interleukin-27 subunit beta (IL-27b))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp EBI3 est non-conjugé

Application: ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: EBI3-8902

Détail du produit anti-EBI3 anticorps

Épitope: AA 366-466

Fonction: EBI3 Antibody / Epstein-Barr virus induced 3

Purification: Protein A/G affinity

Immunogène: A recombinant partial protein sequence (within amino acids 366-466) from the human protein was used as the immunogen for the EBI3 antibody.

Isotype: IgG2b, kappa

Information d'application

Indications d'application: Optimal dilution of the EBI3 antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Aliquot the EBI3 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Détails sur EBI3

Antigène: EBI3 (IL-27b) (Interleukin-27 subunit beta (IL-27b))

Autre désignation: EBI3

Sujet: Epstein-Barr virus-induced gene 3 (Ebi3) is a widely expressed homolog to the interleukin IL-12 p40 subunit protein that forms a heterodimer with either IL-12 p35 or an IL-12 p35 homolog, p28, to create a new cytokine (IL-27). IL-27 is an early product of activated antigen-presenting cells and drives rapid clonal expansion of naive but not memory CD4+ T cells. Interferon-b differentially regulates expression of the IL-12 family members p35, p40, p19 and Ebi3 in activated human dendritic cells. Ebi3 may function to antagonize IL-12 and to inhibit the development of a Th1 immune response. Ebi3 is strongly expressed in Hodgkin and Reed-Sternberg cells, independently of the EBV status of the tumor cells. Research suggests that Ebi3 may be an additional component of the repertoire employed by Hodgkin and Reed-Sternberg cells to inhibit an effective anti-tumor or anti-viral immune response. The human Ebi3 gene maps to chromosome 19p13.3 and encodes a secreted glycoprotein that is expressed in spleen and tonsils, and at high levels in full-term placenta.

UniProt: Q14213