EIF3H anticorps (AA 37-352)

N° du produit ABIN7874398

Cet anticorps anti-EIF3H Polyclonal Lapin (ABIN7874398) détecte spécifiquement EIF3H dans WB, ELISA, IHC et FACS. L’anticorps est réactif avec des échantillons de Humain, Souris et Rat.

Aperçu rapide pour EIF3H anticorps (AA 37-352) (ABIN7874398)

Antigène: EIF3H (Eukaryotic Translation Initiation Factor 3 Subunit H (EIF3H))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp EIF3H est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Flow Cytometry (FACS)

Détail du produit anti-EIF3H anticorps

Épitope: AA 37-352

Fonction: EIF3H Antibody / Eukaryotic translation initiation factor 3 subunit H

Purification: Immunogen affinity purified

Immunogène: E.coli-derived human EIF3H recombinant protein (Position: K37-N352) was used as the immunogen for the EIF3H antibody.

Isotype: IgG

Information d'application

Indications d'application: Optimal dilution of the EIF3H antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Stock: 4 °C,-20 °C

Stockage commentaire: After reconstitution, the EIF3H antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Détails sur EIF3H

Antigène: EIF3H (Eukaryotic Translation Initiation Factor 3 Subunit H (EIF3H))

Autre désignation: EIF3H

Sujet: EIF3H Antibody is used to study Eukaryotic translation initiation factor 3 subunit H, a core component of the eIF3 complex that orchestrates early steps of protein synthesis. As part of the multi-subunit eIF3 scaffold, Eukaryotic translation initiation factor 3 subunit H helps recruit the 40S ribosomal subunit, stabilizes the ternary complex, and promotes mRNA attachment and scanning to locate the start codon. By coordinating factor exchange and ribosome positioning, Eukaryotic translation initiation factor 3 subunit H contributes to the efficiency and selectivity of translation initiation, a checkpoint that powerfully shapes proteome output and cellular phenotype.

Functionally, Eukaryotic translation initiation factor 3 subunit H supports assembly of the 43S pre-initiation complex and helps maintain interactions with eIF4F-bound mRNAs. Perturbations in subunit stoichiometry can shift translation of specific mRNA cohorts, including transcripts with structured 5' UTRs or upstream open reading frames. In cancer models, amplification or overexpression of Eukaryotic translation initiation factor 3 subunit H correlates with elevated global translation and selective enhancement of growth-promoting messages. These properties make EIF3H Antibody valuable for charting how initiation control intersects with oncogenic signaling and stress adaptation.

In the laboratory, EIF3H Antibody enables detection of the native subunit in immunoblotting, monitors changes during serum starvation or mTOR pathway modulation, and supports co-immunoprecipitation to define interactions within the eIF3 complex. In immunofluorescence, the antibody reveals cytoplasmic distribution patterns that can be aligned with ribosomal markers or stress granule components. Researchers coupling EIF3H Antibody with polysome profiling, ribosome footprinting, or cap-binding assays can connect subunit abundance to translational throughput and transcript selectivity. Because initiation control influences cell growth, differentiation, and stress resilience, accurate measurement of this subunit helps interpret the translational state of diverse cell types.

The EIF3H Antibody from NSJ Bioreagents is optimized for robust detection across common cell lines and tissues, integrating cleanly into workflows that probe translation factor dynamics, response to kinase inhibitors, or adaptive reprogramming under hypoxia and nutrient limitation. In biomarker studies, it can help assess whether elevated Eukaryotic translation initiation factor 3 subunit H accompanies genomic gains at the EIF3H locus and whether this associates with proliferative phenotypes. In mechanistic projects, the antibody supports mapping of subunit-subunit interactions and evaluation of how initiation factor balance governs selective translation under stress or therapy.

As translation control emerges as a central driver of cell behavior, EIF3H Antibody provides a dependable means to quantify and localize a key eIF3 subunit, enabling researchers to connect molecular initiation events to system-level outcomes in development, cancer, and stress biology.

UniProt: O15372

Pathways: Ribonucleoprotein Complex Subunit Organization