Recombinant MSH6 anticorps (AA 374-540)

N° du produit ABIN7874436

L’anticorps anti-MSH6 Monoclonal Lapin est utilisé pour la détection de MSH6 dans des échantillons de Humain. Il a été validé pour IHC (p).

Aperçu rapide pour Recombinant MSH6 anticorps (AA 374-540) (ABIN7874436)

Antigène: MSH6 (MutS Homolog 6 (E. Coli) (MSH6))

Type d'anticorp: Recombinant Antibody

Reactivité: Humain

Hôte: Lapin

Clonalité: Monoclonal

Conjugué: Cet anticorp MSH6 est non-conjugé

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Classe de qualité: Carrier-free

Clone: MSH6-7065R

Détail du produit anti-MSH6 anticorps

Épitope: AA 374-540

Fonction: Recombinant MSH6 Antibody (azide and preservative free)

Purification: Protein A/G affinity

Immunogène: A portion of amino acids 374-540was used as the immunogen for the recombinant MSH6 antibody.

Isotype: IgG

Information d'application

Indications d'application: Optimal dilution of the recombinant MSH6 antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Agent conservateur: Azide free

Stock: -20 °C

Stockage commentaire: Aliquot the recombinant MSH6 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Détails sur MSH6

Antigène: MSH6 (MutS Homolog 6 (E. Coli) (MSH6))

Autre désignation: MSH6

Sujet: The finding that mutations in DNA mismatch repair genes are associated with hereditary nonpolyposis colorectal cancer (HNPCC) has resulted in considerable interest in the understanding of the mechanism of DNA mismatch repair. Initially, inherited mutations in the MSH2 and MLH1 homologs of the bacterial DNA mismatch repair genes mutS and mutL were demonstrated at high frequency in HNPCC and were shown to be associated with microsatellite instability. A member of the mismatch repair family, GTBP (also designated MSH6), is an MSH2-related protein that binds to DNA containing G/T mismatches. Findings suggest that the mismatch-binding factor in human cells is composed of a heterodimer of GTBP and MSH2.

UniProt: P52701

Pathways: Réparation de l'ADN, Chromatin Binding, Production of Molecular Mediator of Immune Response