STAR anticorps (AA 39-108)

N° du produit ABIN7874564

Cet anticorps Souris Monoclonal détecte spécifiquement STAR dans IHC (p). Il présente une réactivité avec des échantillons de Humain.

Aperçu rapide pour STAR anticorps (AA 39-108) (ABIN7874564)

Antigène: STAR (Steroidogenic Acute Regulatory Protein (STAR))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp STAR est non-conjugé

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: STAR-2154

Détail du produit anti-STAR anticorps

Épitope: AA 39-108

Fonction: StAR Antibody / Steroidogenic acute regulatory protein

Purification: Protein G affinity chromatography

Immunogène: A portion of amino acids 39-108 from the human protein was used as the immunogen for this StAR antibody.

Isotype: IgG1, kappa

Information d'application

Indications d'application: The concentration stated for each application is a general starting point. Variations in protocols, secondaries and substrates may require the StAR antibody to be titered up or down for optimal performance.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store the StAR antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Détails sur STAR

Antigène: STAR (Steroidogenic Acute Regulatory Protein (STAR))

Autre désignation: StAR

Sujet: Steroidogenic Acute Regulatory Protein (STAR) controls the rate-limiting step of steroidegenesis by translocating cholesterol from the outer mitochondrial membrane to the inner membrane where it is later cleaved to pregnenolone. It is primarily present in steroid-producing cells, including Leydig cells in the testis, theca cells and luteal cells in the ovary and adrenal cells in the adrenal cortex. Due to low levels of pregnenolone, seminomas and Leydig cell tumors display no specific STAR staining. Therefore, STAR antibody may assist in differentiating sex cord stromal tumors (SCST), seminomas and embryonal carcinomas.

UniProt: P49675

Pathways: Metabolism of Steroid Hormones and Vitamin D, Response to Growth Hormone Stimulus, C21-Steroid Hormone Metabolic Process, Cellular Response to Molecule of Bacterial Origin, Carbohydrate Homeostasis