MYBBP1A anticorps (AA 39-1316)

N° du produit ABIN7874570

Cet anticorps Lapin Polyclonal détecte spécifiquement MYBBP1A dans WB, ELISA, IF et ICC. Il présente une réactivité avec des échantillons de Souris et Rat.

Aperçu rapide pour MYBBP1A anticorps (AA 39-1316) (ABIN7874570)

Antigène: MYBBP1A (Myb-Binding Protein 1A (MYBBP1A))

Reactivité: Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MYBBP1A est non-conjugé

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)

Détail du produit anti-MYBBP1A anticorps

Épitope: AA 39-1316

Fonction: MYBBP1A Antibody / Myb-binding protein 1A

Purification: Immunogen affinity purified

Immunogène: E.coli-derived mouse MYBBP1A recombinant protein (Position: D39-R1316) was used as the immunogen for the MYBBP1A antibody.

Isotype: IgG

Information d'application

Indications d'application: Optimal dilution of the MYBBP1A antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Stock: 4 °C,-20 °C

Stockage commentaire: After reconstitution, the MYBBP1A antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Détails sur MYBBP1A

Antigène: MYBBP1A (Myb-Binding Protein 1A (MYBBP1A))

Autre désignation: MYBBP1A

Sujet: MYBBP1A antibody detects Myb-binding protein 1A, a nucleolar transcriptional regulator that modulates gene expression, chromatin structure, and cell cycle progression. Encoded by the MYBBP1A gene on chromosome 17p13.3, this large nuclear protein was originally identified through its interaction with the Myb oncoprotein, but it also binds multiple transcription factors including p53, NF?B, and STAT3. MYBBP1A contains several acidic and coiled-coil domains that facilitate protein-protein interactions and nucleolar localization sequences that target it to the nucleolus under normal growth conditions. It functions as both a transcriptional coactivator and corepressor, integrating stress responses with cell cycle control.

MYBBP1A plays a key role in ribosome biogenesis and nucleolar stress signaling. Upon cellular stress or energy depletion, MYBBP1A translocates from the nucleolus to the nucleoplasm, where it enhances p53 acetylation and activation, promoting cell cycle arrest and apoptosis. It also suppresses c-Myb-driven transcription to prevent uncontrolled proliferation. Through these mechanisms, MYBBP1A acts as a tumor suppressor and regulator of growth arrest. Depletion of MYBBP1A leads to impaired rRNA processing and increased genomic instability. Dysregulation of its expression has been reported in renal carcinoma, hepatocellular carcinoma, and hematologic malignancies.

The MYBBP1A antibody is used in cancer biology and transcriptional regulation studies to detect Myb-binding protein 1A localization and abundance. Western blot analysis typically identifies a ~150 kilodalton band, while immunofluorescence shows predominant nucleolar staining with redistribution upon stress. Because MYBBP1A interacts with both histone-modifying enzymes and transcriptional machinery, it is a critical factor for understanding nucleolar function and epigenetic regulation. The antibody is effective in chromatin immunoprecipitation, immunohistochemistry, and nuclear fractionation assays. The MYBBP1A antibody therefore supports research on tumor suppression, transcriptional control, and nucleolar biology. NSJ Bioreagents provides this reagent validated for high specificity and reproducibility across applications.

UniProt: Q7TPV4