UPF3A anticorps (AA 4-452)

N° du produit ABIN7874678

Cet anticorps Lapin Polyclonal détecte spécifiquement UPF3A dans WB, ELISA, IF et FACS. Il présente une réactivité avec des échantillons de Humain.

Aperçu rapide pour UPF3A anticorps (AA 4-452) (ABIN7874678)

Antigène: UPF3A (UPF3 Regulator of Nonsense Transcripts Homolog A (UPF3A))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp UPF3A est non-conjugé

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Flow Cytometry (FACS)

Détail du produit anti-UPF3A anticorps

Épitope: AA 4-452

Fonction: RENT3A Antibody / UPF3A

Purification: Affinity purified

Immunogène: Recombinant human protein (amino acids E4-E452) was used as the immunogen for the RENT3A antibody.

Isotype: IgG

Information d'application

Indications d'application: Optimal dilution of the RENT3A antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Stock: 4 °C,-20 °C

Stockage commentaire: After reconstitution, the RENT3A antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Détails sur UPF3A

Antigène: UPF3A (UPF3 Regulator of Nonsense Transcripts Homolog A (UPF3A))

Autre désignation: RENT3A

Sujet: Regulator of nonsense transcripts 3A is a protein that in humans is encoded by the UPF3A gene. This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. The encoded protein is one of two functional homologs to yeast Upf3p. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein binds to the mRNA and remains bound after nuclear export, acting as a nucleocytoplasmic shuttling protein. It forms with Y14 a complex that binds specifically 20 nt upstream of exon-exon junctions. This gene is located on the long arm of chromosome 13. Several splice variants encoding different isoforms have been found for this gene.

UniProt: Q9H1J1