SPRED2 anticorps (AA 40-298)

N° du produit ABIN7874694

L’anticorps anti-SPRED2 Polyclonal Lapin est utilisé pour la détection de SPRED2 dans des échantillons de Humain, Souris et Rat. Il a été validé pour WB, ELISA, IHC (p), IF et FACS.

Aperçu rapide pour SPRED2 anticorps (AA 40-298) (ABIN7874694)

Antigène: SPRED2 (Sprouty-Related, EVH1 Domain Containing 2 (SPRED2))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SPRED2 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF), Flow Cytometry (FACS)

Détail du produit anti-SPRED2 anticorps

Épitope: AA 40-298

Fonction: SPRED2 Antibody / Sprouty-related EVH1 domain-containing protein 2

Purification: Antigen affinity purified

Immunogène: Amino acids R40-R298 from the human protein were used as the immunogen for the SPRED2 antibody.

Isotype: IgG

Information d'application

Indications d'application: Optimal dilution of the SPRED2 antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Stock: 4 °C,-20 °C

Stockage commentaire: After reconstitution, the SPRED2 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Détails sur SPRED2

Antigène: SPRED2 (Sprouty-Related, EVH1 Domain Containing 2 (SPRED2))

Autre désignation: SPRED2

Sujet: SPRED2 (Sprouty-related EVH1 domain-containing protein 2) is a member of the SPRED protein family, which negatively regulates receptor tyrosine kinase (RTK) signaling pathways. By interacting with components of the Ras/MAPK cascade, SPRED2 suppresses excessive ERK activation, thereby controlling cellular processes such as proliferation, differentiation, and migration. Researchers frequently use a SPRED2 antibody to investigate signaling dynamics and the molecular mechanisms of growth factor regulation.

SPRED2 contains an N-terminal Ena/VASP homology 1 (EVH1) domain, a central c-Kit binding domain, and a C-terminal Sprouty-related cysteine-rich domain. These structural motifs allow SPRED2 to localize to the plasma membrane and recruit signaling proteins, where it inhibits Ras and Raf activation. Employing a SPRED2 antibody allows scientists to study how this protein maintains signaling balance across a variety of cell types.

Altered expression of SPRED2 has been linked to human disease. Loss or reduction of SPRED2 function has been associated with enhanced MAPK pathway activity, which may contribute to oncogenesis and abnormal tissue growth. Additionally, SPRED2 is studied in the context of immune regulation and inflammation, where dysregulated signaling can lead to pathological outcomes. Using a SPRED2 antibody supports research into these processes and offers insight into therapeutic strategies aimed at modulating Ras/MAPK signaling.

NSJ Bioreagents offers a high-quality SPRED2 antibody validated for applications such as western blot, immunohistochemistry, and immunofluorescence. Choosing a SPRED2 antibody from NSJ Bioreagents ensures reliable detection and reproducible performance in studies of signal transduction, cell regulation, and disease biology.

UniProt: Q7Z698