C9ORF72 anticorps (AA 40-77)

N° du produit ABIN7874711

Cet anticorps Lapin Polyclonal détecte spécifiquement C9ORF72 dans WB et IHC (p). Il présente une réactivité avec des échantillons de Poisson zèbre (Danio rerio).

Aperçu rapide pour C9ORF72 anticorps (AA 40-77) (ABIN7874711)

Antigène: C9ORF72 (Chromosome 9 Open Reading Frame 72 (C9ORF72))

Reactivité: Poisson zèbre (Danio rerio)

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp C9ORF72 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Détail du produit anti-C9ORF72 anticorps

Épitope: AA 40-77

Fonction: Zebrafish C9orf72 Antibody

Purification: Antigen affinity chromatography

Immunogène: An E.coli-derived zebrafish C9orf72 recombinant protein (amino acids R40-E77) was used as the immunogen for the Zebrafish C9orf72 antibody.

Isotype: Ig Fraction

Information d'application

Indications d'application: Optimal dilution of the Zebrafish C9orf72 antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Stock: 4 °C,-20 °C

Stockage commentaire: After reconstitution, the Zebrafish C9orf72 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Détails sur C9ORF72

Antigène: C9ORF72 (Chromosome 9 Open Reading Frame 72 (C9ORF72))

Autre désignation: C9orf72

Sujet: C9orf72 (chromosome 9 open reading frame 72) is a protein which in humans is encoded by the gene C9orf72. It is mapped to 9p21.2. The protein encoded by this gene plays an important role in the regulation of endosomal trafficking, and has been shown to interact with Rab proteins that are involved in autophagy and endocytic transport. Expansion of a GGGGCC repeat from 2-22 copies to 700-1600 copies in the intronic sequence between alternate 5' exons in transcripts from this gene is associated with 9p-linked ALS (amyotrophic lateral sclerosis) and FTD (frontotemporal dementia) (PMID: 21944778, 21944779). Studies suggest that hexanucleotide expansions could result in the selective stabilization of repeat-containing pre-mRNA, and the accumulation of insoluble dipeptide repeat protein aggregates that could be pathogenic in FTD-ALS patients (PMID: 23393093). Alternative splicing results in multiple transcript variants encoding different isoforms.

UniProt: Q6TLH8