MX1 anticorps (AA 400-592)

N° du produit ABIN7874736

L’anticorps anti-MX1 Monoclonal Souris est utilisé pour la détection de MX1 dans des échantillons de Humain. Il a été validé pour IHC (p).

Aperçu rapide pour MX1 anticorps (AA 400-592) (ABIN7874736)

Antigène: MX1 (Myxovirus Resistance Protein 1 (MX1))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp MX1 est non-conjugé

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: MX1-7530

Détail du produit anti-MX1 anticorps

Épitope: AA 400-592

Fonction: Myxovirus resistance protein 1 Antibody / MX1 / MxA

Purification: Protein A/G affinity

Immunogène: A recombinant partial protein sequence (within amino acids 400-592) from the human protein was used as the immunogen for the Myxovirus resistance protein 1 antibody.

Isotype: IgG2, kappa

Information d'application

Indications d'application: Optimal dilution of the Myxovirus resistance protein 1 antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Aliquot the Myxovirus resistance protein 1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Détails sur MX1

Antigène: MX1 (Myxovirus Resistance Protein 1 (MX1))

Autre désignation: Myxovirus resistance protein 1

Sujet: The Dynamin family of microtubule-associated proteins function as GTPases that are involved in microtubule bundling and endocytosis. In mice, Mx2 (myxovirus resistance protein 2) and Mx1 (myxovirus resistance protein 1) are members of the Dynamin family that are involved in the immune response to viral infections. Localized to the cytoplasm, Mx2 contains one GED domain and is expressed in response to viral infection or treatment by IFN-a/IFN-b. Once expression is induced, Mx2 accumulates in the cytoplasm and inhibits the replication of vesicular stomatitis virus (VSV), thereby conferring resistance to VSV infection. Unlike Mx2, Mx1 is localized to the nucleus where, upon induction by IFN-a/IFN-b, it provides selective resistance to infection by the highly lethal H5N1 influenza virus. In humans, MxA and MxB function in a similar manner to Mx1 and Mx2, conferring resistance to specific target viruses. Mx3 is a rat-specific member of the myxovirus resistance protein family.

UniProt: P20591