MYBBP1A anticorps (AA 41-1058)

N° du produit ABIN7874821

Cet anticorps anti-MYBBP1A Polyclonal Lapin (ABIN7874821) détecte spécifiquement MYBBP1A dans WB, ELISA, IF, ICC et FACS. L’anticorps est réactif avec des échantillons de Humain, Souris et Rat.

Aperçu rapide pour MYBBP1A anticorps (AA 41-1058) (ABIN7874821)

Antigène: MYBBP1A (Myb-Binding Protein 1A (MYBBP1A))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MYBBP1A est non-conjugé

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC), Flow Cytometry (FACS)

Détail du produit anti-MYBBP1A anticorps

Épitope: AA 41-1058

Fonction: MYBBP1A Antibody / Myb-binding protein 1A

Purification: Immunogen affinity purified

Immunogène: E.coli-derived human MYBBP1A recombinant protein (Position: D41-Q1058) was used as the immunogen for the MYBBP1A antibody.

Isotype: IgG

Information d'application

Indications d'application: Optimal dilution of the MYBBP1A antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Stock: 4 °C,-20 °C

Stockage commentaire: After reconstitution, the MYBBP1A antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Détails sur MYBBP1A

Antigène: MYBBP1A (Myb-Binding Protein 1A (MYBBP1A))

Autre désignation: MYBBP1A

Sujet: MYBBP1A antibody detects Myb-binding protein 1A, encoded by the MYBBP1A gene. Myb-binding protein 1A is a nucleolar protein that participates in transcriptional regulation, ribosome biogenesis, and stress signaling. MYBBP1A antibody provides researchers with a versatile reagent for studying nuclear protein interactions, tumor suppression, and stress-responsive transcriptional programs.

Myb-binding protein 1A was first identified as a factor that interacts with the transcription factor c-Myb. Research using MYBBP1A antibody has shown that it acts as a transcriptional regulator by modulating Myb-dependent genes and other transcriptional pathways. It functions as a co-repressor or co-activator depending on cellular context, influencing cell proliferation and differentiation.

Studies with MYBBP1A antibody have revealed that the protein localizes to the nucleolus under basal conditions but translocates to the nucleoplasm upon cellular stress. This dynamic distribution links ribosome biogenesis to stress-responsive transcriptional regulation. MYBBP1A influences ribosomal RNA transcription, p53 activation, and chromatin remodeling, emphasizing its multifunctional nature.

Dysregulation of Myb-binding protein 1A has been linked to cancer and stress-related pathology. Research using MYBBP1A antibody has shown that reduced expression contributes to tumorigenesis by impairing p53-mediated responses. Conversely, overexpression can suppress tumor growth by activating apoptosis pathways. This dual role highlights its complex involvement in cancer biology.

Beyond cancer, MYBBP1A participates in metabolic regulation and cellular senescence. Research using MYBBP1A antibody has suggested roles in controlling NF-kB signaling, mitochondrial stress responses, and transcription of metabolic genes. These findings underscore its integration of stress responses with transcriptional networks.

MYBBP1A antibody is widely applied in western blotting, immunohistochemistry, and chromatin immunoprecipitation. Western blotting quantifies protein levels, immunohistochemistry demonstrates nucleolar localization, and chromatin immunoprecipitation identifies transcriptional binding partners. These applications make MYBBP1A antibody indispensable in nuclear biology and cancer research.

By providing validated MYBBP1A antibody reagents, NSJ Bioreagents supports studies into transcriptional regulation, stress signaling, and tumor suppression. Detection of Myb-binding protein 1A provides researchers with insight into how nucleolar proteins integrate ribosome biogenesis and stress responses.

UniProt: Q9BQG0