Perforin 1 anticorps (AA 413-552)

N° du produit ABIN7874879

Cet anticorps Souris Monoclonal détecte spécifiquement Perforin 1 dans IHC (p). Il présente une réactivité avec des échantillons de Humain.

Aperçu rapide pour Perforin 1 anticorps (AA 413-552) (ABIN7874879)

Antigène: Perforin 1 (PRF1) (Perforin 1 (Pore Forming Protein) (PRF1))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Perforin 1 est non-conjugé

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: PRF1-2470

Détail du produit anti-Perforin 1 anticorps

Épitope: AA 413-552

Fonction: Perforin Antibody / PRF1

Purification: Protein G affinity

Immunogène: A portion of amino acids 413-552 from the human protein was used as the immunogen for the Perforin antibody.

Isotype: IgG2c, kappa

Information d'application

Indications d'application: Optimal dilution of the Perforin antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store the Perforin antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Détails sur Perforin 1

Antigène: Perforin 1 (PRF1) (Perforin 1 (Pore Forming Protein) (PRF1))

Autre désignation: Perforin

Sujet: Perforin is a pore-forming protein that leads to osmotic lysis of the target cells and subsequently enables granzymes to enter the target cells and activate apoptosis. Perforin has structural and functional similarities to complement component 9 (C9). Like C9, this protein creates transmembrane tubules and is capable of lysing non-specifically a variety of target cells. It is one of the main cytolytic proteins of cytolytic granules, and is known to be a key effector molecule for T-cell- and natural killer-cell-mediated cytolysis. Defects in this gene cause familial hemophagocytic lymphohistiocytosis type 2 (HPLH2), a rare and lethal autosomal recessive disorder of early childhood. The expression of perforin is reportedly upregulated in activated CD8+ T-cells, natural killer cells and some CD4+ T-cells.

UniProt: P14222

Pathways: Apoptose, Caspase Cascade in Apoptosis