Recombinant TdT anticorps (AA 52-192)

N° du produit ABIN7875550

Cet anticorps anti-TdT Monoclonal Lapin (Clone DNTT-4617R) (ABIN7875550) détecte spécifiquement TdT dans IHC (p). L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour Recombinant TdT anticorps (AA 52-192) (ABIN7875550)

Antigène: TdT (DNTT) (Deoxynucleotidyltransferase, terminal (DNTT))

Type d'anticorp: Recombinant Antibody

Reactivité: Humain

Hôte: Lapin

Clonalité: Monoclonal

Conjugué: Cet anticorp TdT est non-conjugé

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: DNTT-4617R

Détail du produit anti-TdT anticorps

Épitope: AA 52-192

Fonction: Recombinant TdT Antibody / DNA nucleotidylexotransferase

Purification: Protein A/G affinity

Immunogène: A portion of amino acids 52-192 was used as the immunogen for the recombinant TdT antibody.

Isotype: IgG, kappa

Information d'application

Indications d'application: Optimal dilution of the recombinant TdT antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Aliquot the recombinant TdT antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Détails sur TdT

Antigène: TdT (DNTT) (Deoxynucleotidyltransferase, terminal (DNTT))

Autre désignation: TdT

Sujet: Terminal deoxynucleotidyl transferase (TdT) is an unusual deoxynucleotide polymerizing enzyme with a molecular weight of about 58 kDa found normally only in B- and T-cell lymphoblasts/prelymphocytes. TdT generates antigen receptor diversity by synthesizing non-germ line elements (N-regions) at the junctions of rearranged Ig heavy chain and T cell receptor gene segments. Rare TdT-positive cells are regularly detected in thymus and bone marrow. Typically, TdT expression in the thymus is very variable from cell to cell since it is rapidly decreased in more mature T-cells. TdT-positive cells may occasionally be found in tonsils, lymph nodes and extranodal lymphoid tissue. Immunohistochemical detection of TdT has value in classification of malignant lymphomas and acute leukemias, particularly for the identification of pre-B and pre-T acute lymphoblastic leukemia/lymphoblastic lymphoma (ALL/LBL).

UniProt: P04053

Pathways: Réparation de l'ADN