MERTK anticorps (AA 55-148)

N° du produit ABIN7875676

Cet anticorps anti-MERTK Monoclonal Souris (Clone MERTK-3024) (ABIN7875676) détecte spécifiquement MERTK dans IHC (p). L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour MERTK anticorps (AA 55-148) (ABIN7875676)

Antigène: MERTK (C-Mer Proto-Oncogene Tyrosine Kinase (MERTK))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp MERTK est non-conjugé

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Classe de qualité: Carrier-free

Clone: MERTK-3024

Détail du produit anti-MERTK anticorps

Épitope: AA 55-148

Fonction: MERTK Antibody (azide and preservative free)

Purification: Protein A/G affinity

Immunogène: A portion of amino acids 55-148 was used as the immunogen for the MERTK antibody.

Isotype: IgG2a

Information d'application

Indications d'application: Optimal dilution of the MERTK antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Agent conservateur: Azide free

Stock: -20 °C

Stockage commentaire: Aliquot the MERTK antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Détails sur MERTK

Antigène: MERTK (C-Mer Proto-Oncogene Tyrosine Kinase (MERTK))

Autre désignation: MERTK

Sujet: MERTK, also called c-Mer, is a member of the Mer/Axl/Tyro3 receptor kinase family. It is a 984 residue transmembrane protein made up of one tyrosine kinase domain, two Fibronectin type-III domains and two immunoglobulinlike C2-type domains. MERTK is the mammalian ortholog of the chicken retroviral oncogene product v-Eyk. This protein plays a critical role in macrophage activation, platelet aggregation, clot stability and the efficient removal of apoptotic cells. Specifically, MERTK acts as a signaling molecule, triggering outer segment ingestion in the retinal pigment epithelium (RPE) phagocytic process. Evidence suggests that MERTK signals via interaction with phosphatidylinositol-specific phospholipase C 2). When the gene encoding for MERTK is mutated, the RPE phagocytosis pathway is disrupted and autosomal recessive retinitis pigmentosa (RP) may result, leading to degeneration of retinal photoreceptor cells.

UniProt: Q12866

Pathways: Signalisation RTK