MERTK anticorps (AA 55-148)

N° du produit ABIN7875679

Cet anticorps anti-MERTK Monoclonal Souris (Clone TPKR-1) (ABIN7875679) détecte spécifiquement MERTK dans IHC (p). L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour MERTK anticorps (AA 55-148) (ABIN7875679)

Antigène: MERTK (C-Mer Proto-Oncogene Tyrosine Kinase (MERTK))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp MERTK est non-conjugé

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: TPKR-1

Détail du produit anti-MERTK anticorps

Épitope: AA 55-148

Fonction: MerTK Antibody

Purification: Protein G affinity chromatography

Immunogène: Amino acids 55-148 were used as the immunogen for the MerTK antibody.

Isotype: IgG2a, kappa

Information d'application

Indications d'application: The stated application concentrations are suggested starting points. Titration of the MerTK antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store the MerTK antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Détails sur MERTK

Antigène: MERTK (C-Mer Proto-Oncogene Tyrosine Kinase (MERTK))

Autre désignation: MerTK

Sujet: Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including LGALS3, TUB, TULP1 or GAS6. Regulates many physiological processes including cell survival, migration, differentiation, and phagocytosis of apoptotic cells (efferocytosis). Ligand binding at the cell surface induces autophosphorylation of MERTK on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with GRB2 or PLCG2 and induces phosphorylation of MAPK1, MAPK2, FAK/PTK2 or RAC1. MERTK signaling plays a role in various processes such as macrophage clearance of apoptotic cells, platelet aggregation, cytoskeleton reorganization and engulfment. Functions in the retinal pigment epithelium (RPE) as a regulator of rod outer segments fragments phagocytosis. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3. [UniProt]

UniProt: Q12866

Pathways: Signalisation RTK