MERTK anticorps (AA 55-148)

N° du produit ABIN7875681

L’anticorps anti-MERTK Monoclonal Souris est utilisé pour la détection de MERTK dans des échantillons de Humain. Il a été validé pour IHC (p).

Aperçu rapide pour MERTK anticorps (AA 55-148) (ABIN7875681)

Antigène: MERTK (C-Mer Proto-Oncogene Tyrosine Kinase (MERTK))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp MERTK est non-conjugé

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: MERTK-3022

Détail du produit anti-MERTK anticorps

Épitope: AA 55-148

Fonction: MerTK Antibody

Purification: Protein G affinity chromatography

Immunogène: A recombinant human partial protein (amino acids 55-148) was used as the immunogen for the MerTK antibody.

Isotype: IgG2a

Information d'application

Indications d'application: Optimal dilution of the MerTK antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store the MerTK antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Détails sur MERTK

Antigène: MERTK (C-Mer Proto-Oncogene Tyrosine Kinase (MERTK))

Autre désignation: MerTK

Sujet: MerTK, also called c-Mer, is a member of the Mer/Axl/Tyro3 receptor kinase family. It is a 984 residue transmembrane protein made up of one tyrosine kinase domain, two Fibronectin type-III domains and two immunoglobulinlike C2-type domains. MerTK is the mammalian ortholog of the chicken retroviral oncogene product v-Eyk. This protein plays a critical role in macrophage activation, platelet aggregation, clot stability and the efficient removal of apoptotic cells. Specifically, MerTK acts as a signaling molecule, triggering outer segment ingestion in the retinal pigment epithelium (RPE) phagocytic process. Evidence suggests that MerTK signals via interaction with phosphatidylinositol-specific phospholipase C 2). When the gene encoding for MerTK is mutated, the RPE phagocytosis pathway is disrupted and autosomal recessive retinitis pigmentosa (RP) may result, leading to degeneration of retinal photoreceptor cells.

UniProt: Q12866

Pathways: Signalisation RTK