alpha Sarcomeric Actin (AA 557-692) anticorps

N° du produit ABIN7875752

Cet anticorps Souris Monoclonal détecte spécifiquement alpha Sarcomeric Actin dans IHC (p) et WB. Il présente une réactivité avec des échantillons de Humain.

Aperçu rapide pour alpha Sarcomeric Actin (AA 557-692) anticorps (ABIN7875752)

Antigène: alpha Sarcomeric Actin

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Inconjugué

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)

Clone: ACTN2-3292

Détail du produit

Épitope: AA 557-692

Fonction: Sarcomeric Alpha Actinin Antibody / ACTN2

Purification: Protein G affinity chromatography

Immunogène: Amino acids 557-692 from the human protein were used as the immunogen for this Sarcomeric Alpha Actinin antibody.

Isotype: IgG2b, kappa

Information d'application

Indications d'application: The optimal dilution of the Sarcomeric Alpha Actinin antibody for each application should be determined by the researcher.

1. The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store the Sarcomeric Alpha Actinin antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Détail du antigène

Antigène: alpha Sarcomeric Actin

Autre désignation: Sarcomeric Alpha Actinin

Sujet: Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In non-muscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a muscle-specific, alpha actinin isoform that is expressed in both skeletal and cardiac muscles. Several transcript variants encoding different isoforms have been found for this gene.

UniProt: P35609