SMC1A anticorps (AA 59-1233)

N° du produit ABIN7875873

L’anticorps anti-SMC1A Polyclonal Lapin est utilisé pour la détection de SMC1A dans des échantillons de Humain. Il a été validé pour WB, ELISA et IF.

Aperçu rapide pour SMC1A anticorps (AA 59-1233) (ABIN7875873)

Antigène: SMC1A (Structural Maintenance of Chromosomes 1A (SMC1A))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SMC1A est non-conjugé

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF)

Détail du produit anti-SMC1A anticorps

Épitope: AA 59-1233

Fonction: SMC1A Antibody / Structural maintenance of chromosomes protein 1A

Purification: Antigen affinity purified

Immunogène: E. coli-derived recombinant human protein (amino acids K59-Q1233) was used as the immunogen for the SMC1A antibody.

Isotype: IgG

Information d'application

Indications d'application: Optimal dilution of the SMC1A antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Stock: 4 °C,-20 °C

Stockage commentaire: After reconstitution, the SMC1A antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Détails sur SMC1A

Antigène: SMC1A (Structural Maintenance of Chromosomes 1A (SMC1A))

Autre désignation: SMC1A

Sujet: Structural maintenance of chromosomes protein 1A (SMC1A) is a protein that in humans is encoded by the SMC1A gene. Proper cohesion of sister chromatids is a prerequisite for the correct segregation of chromosomes during cell division. The cohesin multiprotein complex is required for sister chromatid cohesion. This complex is composed partly of two structural maintenance of chromosomes (SMC) proteins, SMC3 and either SMC1B or the protein encoded by this gene. Most of the cohesin complexes dissociate from the chromosomes before mitosis, although those complexes at the kinetochore remain. Therefore, the encoded protein is thought to be an important part of functional kinetochores. In addition, this protein interacts with BRCA1 and is phosphorylated by ATM, indicating a potential role for this protein in DNA repair. This gene, which belongs to the SMC gene family, is located in an area of the X-chromosome that escapes X inactivation. Mutations in this gene result in Cornelia de Lange syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms.

UniProt: Q14683

Pathways: Stem Cell Maintenance