TNS3 anticorps (AA 592-869)

N° du produit ABIN7875930

L’anticorps anti-TNS3 Polyclonal Lapin est utilisé pour la détection de TNS3 dans des échantillons de Humain. Il a été validé pour IHC, WB, ELISA, IF, IP, ICC et FACS.

Aperçu rapide pour TNS3 anticorps (AA 592-869) (ABIN7875930)

Antigène: TNS3 (Tensin 3 (TNS3))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TNS3 est non-conjugé

Application: Immunohistochemistry (IHC), Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunoprecipitation (IP), Immunocytochemistry (ICC), Flow Cytometry (FACS)

Détail du produit anti-TNS3 anticorps

Épitope: AA 592-869

Fonction: TNS3 Antibody / Tensin 3

Purification: Immunogen affinity purified

Immunogène: E.coli-derived human TNS3 recombinant protein (Position: Q592-E869) was used as the immunogen for the TNS3 antibody.

Isotype: IgG

Information d'application

Indications d'application: Optimal dilution of the TNS3 antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Stock: 4 °C,-20 °C

Stockage commentaire: After reconstitution, the TNS3 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Détails sur TNS3

Antigène: TNS3 (Tensin 3 (TNS3))

Autre désignation: TNS3

Sujet: TNS3 antibody detects Tensin-3, a cytoskeletal adaptor protein that links integrins to the actin cytoskeleton and participates in cell adhesion, migration, and signal transduction. Encoded by the TNS3 gene on chromosome 7p12.3, this protein is part of the tensin family, which plays key roles in focal adhesion dynamics and mechanical signal integration. Tensin-3 contributes to the structural connection between integrin-mediated extracellular matrix adhesion sites and intracellular actin filaments, regulating cellular shape and motility.

Structurally, Tensin-3 contains Src homology 2 (SH2) and phosphotyrosine-binding (PTB) domains that interact with phosphorylated tyrosine residues on focal adhesion proteins and with integrin cytoplasmic tails. Through these domains, TNS3 facilitates recruitment of signaling molecules, including Src family kinases, PI3K, and FAK, at adhesion sites. It also modulates Rho GTPase signaling, influencing actin organization and cell polarity.

The TNS3 antibody is widely used in cancer biology, cytoskeletal research, and cell signaling studies to investigate adhesion remodeling and integrin signaling. Western blot analysis detects a 150-160 kilodalton band corresponding to Tensin-3, while immunofluorescence reveals focal adhesion and cytoplasmic localization. This antibody supports studies examining adhesion turnover, migration, and mechanotransduction pathways in normal and malignant cells.

Tensin-3 expression is frequently altered in cancer, where it influences metastatic potential and invasion by regulating focal adhesion stability and actin remodeling. Overexpression promotes invasive behavior in several carcinoma types, while loss of function impairs migration and cell spreading. The TNS3 antibody provides a reliable reagent for exploring adhesion-mediated signaling and tumor cell motility. NSJ Bioreagents offers this antibody validated for western blotting, immunohistochemistry, and immunofluorescence, ensuring reproducible detection for cytoskeletal and signaling research.

UniProt: Q68CZ2