MST1R anticorps (AA 600-633)

N° du produit ABIN7876001

Cet anticorps Lapin Polyclonal détecte spécifiquement MST1R dans WB. Il présente une réactivité avec des échantillons de Humain.

Aperçu rapide pour MST1R anticorps (AA 600-633) (ABIN7876001)

Antigène: MST1R (Macrophage Stimulating 1 Receptor (C-Met-Related tyrosine Kinase) (MST1R))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MST1R est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-MST1R anticorps

Épitope: AA 600-633

Fonction: RON Antibody / MST1R (Center Region)

Purification: Antigen affinity

Immunogène: A portion of amino acids 600-633 from human MST1R/RON was used as the immunogen for the RON antibody.

Isotype: Ig Fraction

Information d'application

Indications d'application: The stated application concentrations are suggested starting points. Titration of the RON antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Aliquot the RON antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Détails sur MST1R

Antigène: MST1R (Macrophage Stimulating 1 Receptor (C-Met-Related tyrosine Kinase) (MST1R))

Autre désignation: RON

Sujet: Recepteur d'origine nantais (RON) or Macrophage-stimulating protein receptor (MST1R) is a receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to MST1 ligand. Regulates many physiological processes including cell survival, migration and differentiation. Ligand binding at the cell surface induces autophosphorylation of RON on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1 or the adapter GAB1. Recruitment of these downstream effectors by RON leads to the activation of several signaling cascades including the RAS-ERK, PI3 kinase-AKT, or PLCgamma-PKC. RON signaling activates the wound healing response by promoting epithelial cell migration, proliferation as well as survival at the wound site. Plays also a role in the innate immune response by regulating the migration and phagocytic activity of macrophages. Alternatively, RON can also promote signals such as cell migration and proliferation in response to growth factors other than MST1 ligand. [UniProt]

UniProt: Q04912

Pathways: Signalisation RTK