Recombinant Thyroperoxidase anticorps (AA 600-900)

N° du produit ABIN7876061

Cet anticorps Lapin Monoclonal détecte spécifiquement Thyroperoxidase dans IHC (p). Il présente une réactivité avec des échantillons de Humain.

Aperçu rapide pour Recombinant Thyroperoxidase anticorps (AA 600-900) (ABIN7876061)

Antigène: Thyroperoxidase (TPO) (Thyroid Peroxidase (TPO))

Type d'anticorp: Recombinant Antibody

Reactivité: Humain

Hôte: Lapin

Clonalité: Monoclonal

Conjugué: Cet anticorp Thyroperoxidase est non-conjugé

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: TPO-7088R

Détail du produit anti-Thyroperoxidase anticorps

Épitope: AA 600-900

Fonction: Thyroid Peroxidase Antibody / TPO

Purification: Protein A/G affinity

Immunogène: A recombinant fragment of human TPO (within amino acids 600-900) was used as the immunogen for the Thyroid Peroxidase antibody.

Isotype: IgG, kappa

Information d'application

Indications d'application: Optimal dilution of the Thyroid Peroxidase antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Aliquot the Thyroid Peroxidase antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Détails sur Thyroperoxidase

Antigène: Thyroperoxidase (TPO) (Thyroid Peroxidase (TPO))

Autre désignation: Thyroid Peroxidase

Sujet: Thyroperoxidase (TPO) is a 933 amino acid, type I transmembrane glycoprotein that plays a key role in thyroid gland function and autoimmunity. It is present as a dimer on the apical surface of thyroid follicular cells. TPO functions in the iodination of tyrosine residues in thyroglobulin and phenoxy-ester formation between pairs of iodinated tyrosines to generate the thyroid hormones, thyroxine and triiodothyronine. Mutations in this gene are associated with several disorders of thyroid hormonogenesis, including congenital hypothyroidism, congenital goiter, and thyroid hormone organification defect IIA.Malignant thyroid tumors exhibit an anomaly in TPO resulting in lower affinity for anti-TPO. This antibody may aid in the differentiation between benign and malignant thyroid tumors.

UniProt: P07202

Pathways: Thyroid Hormone Synthesis