alpha 2 Macroglobulin anticorps (AA 604-748)

N° du produit ABIN7876081

Cet anticorps anti-alpha 2 Macroglobulin Monoclonal Souris (Clone A2M-3621) (ABIN7876081) détecte spécifiquement alpha 2 Macroglobulin dans IHC (p). L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour alpha 2 Macroglobulin anticorps (AA 604-748) (ABIN7876081)

Antigène: alpha 2 Macroglobulin (A2M) (alpha-2-Macroglobulin (A2M))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp alpha 2 Macroglobulin est non-conjugé

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: A2M-3621

Détail du produit anti-alpha 2 Macroglobulin anticorps

Épitope: AA 604-748

Fonction: Alpha-2-Macroglobulin Antibody / A2M

Purification: Protein G affinity chromatography

Immunogène: A portion of amino acids 604-748 from the human protein was used as the immunogen for the Alpha-2-Macroglobulin antibody.

Isotype: IgG2c, kappa

Information d'application

Indications d'application: Optimal dilution of the Alpha-2-Macroglobulin antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store the Alpha-2-Macroglobulin antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Détails sur alpha 2 Macroglobulin

Antigène: alpha 2 Macroglobulin (A2M) (alpha-2-Macroglobulin (A2M))

Autre désignation: Alpha-2-Macroglobulin

Sujet: Alpha-2-Macroglobulin (A2M) is a homotetrameric serum protein consisting of four identical subunits that form dimers through disulfide bonds. Initially, it was characterized as a pan-proteinase inhibitor that was able to bait proteinases into cleaving specific peptide sequences on A2M. This interaction induces a conformational change, thus enabling it to trap the proteinase and further inhibit its activity. Subsequently, A2M has been shown to function as a carrier protein and regulator of cytokines during inflammation.

UniProt: P01023

Pathways: Lipid Metabolism