alpha 2 Macroglobulin anticorps (AA 604-748)

N° du produit ABIN7876089

L’anticorps anti-alpha 2 Macroglobulin Monoclonal Souris est utilisé pour la détection de alpha 2 Macroglobulin dans des échantillons de Humain. Il a été validé pour IHC (p).

Aperçu rapide pour alpha 2 Macroglobulin anticorps (AA 604-748) (ABIN7876089)

Antigène: alpha 2 Macroglobulin (A2M) (alpha-2-Macroglobulin (A2M))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp alpha 2 Macroglobulin est non-conjugé

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: A2M-4847

Détail du produit anti-alpha 2 Macroglobulin anticorps

Épitope: AA 604-748

Fonction: A2M Antibody / Alpha-2-Macroglobulin

Purification: Protein A/G affinity

Immunogène: A recombinant partial protein sequence (within amino acids 604-748) from the human protein was used as the immunogen for the A2M antibody.

Isotype: IgG2c, kappa

Information d'application

Indications d'application: Optimal dilution of the A2M antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Aliquot the A2M antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Détails sur alpha 2 Macroglobulin

Antigène: alpha 2 Macroglobulin (A2M) (alpha-2-Macroglobulin (A2M))

Autre désignation: A2M

Sujet: Alpha-2-Macroglobulin (Alpha-2M) is a homotetrameric serum protein consisting of four identical subunits that form dimers through disulfide bonds. Initially, Alpha-2M was characterized as a pan-proteinase inhibitor that was able to bait proteinases into cleaving specific peptide sequences on Alpha-2M. This interaction induces a conformational change in Alpha-2M, thus enabling it to trap the proteinase and further inhibit its activity. Subsequently, Alpha-2M has been shown to function as a carrier protein and regulator of cytokines during inflammation. Circulating transforming growth factor beta (TGFbeta) in serum is primarily bound to Alpha-2M, which renders TGFbeta inactive. Alpha-2M also binds to IL-6 and, thereby, increases the concentration of IL-6 near lymphocytes, hepatocytes and stem cells involved in mediating the inflammatory cascade. Mutations and deletions in the gene encoding Alpha-2M are associated with an increased incidence of Alzheimer s disease (AD), which is consistent with the role of Alpha-2M in mediating the clearance and degradation of A beta, the major component of beta-Amyloid deposits accumulated during AD.

UniProt: P01023

Pathways: Lipid Metabolism