TCF12 anticorps (AA 67-300)

N° du produit ABIN7876373

Cet anticorps Lapin Polyclonal détecte spécifiquement TCF12 dans WB, ELISA et FACS. Il présente une réactivité avec des échantillons de Humain, Rat et Souris.

Aperçu rapide pour TCF12 anticorps (AA 67-300) (ABIN7876373)

Antigène: TCF12 (Transcription Factor 12 (TCF12))

Reactivité: Humain, Rat, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TCF12 est non-conjugé

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS)

Détail du produit anti-TCF12 anticorps

Épitope: AA 67-300

Fonction: TCF12 Antibody / Transcription factor 12

Purification: Immunogen affinity purified

Immunogène: E.coli-derived human HEB/TCF12 recombinant protein (Position: S67-G300) was used as the immunogen for the TCF12 antibody.

Isotype: IgG

Information d'application

Indications d'application: Optimal dilution of the TCF12 antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4

Stock: 4 °C,-20 °C

Stockage commentaire: After reconstitution, the TCF12 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Détails sur TCF12

Antigène: TCF12 (Transcription Factor 12 (TCF12))

Autre désignation: TCF12

Sujet: TCF12 antibody detects Transcription factor 12, encoded by the TCF12 gene. Transcription factor 12 is a basic helix-loop-helix transcription factor that regulates gene expression during development, differentiation, and tissue homeostasis. TCF12 antibody provides researchers with a specific reagent for studying transcriptional regulation, developmental pathways, and disease mechanisms involving abnormal transcription factor activity.

Transcription factor 12 dimerizes with other basic helix-loop-helix proteins to bind E-box DNA sequences and regulate gene transcription. Research using TCF12 antibody has shown that it partners with proteins such as E47, E12, and MyoD to control cell fate decisions. Through these interactions, TCF12 coordinates gene networks that drive muscle differentiation, neural development, and hematopoiesis.

Studies with TCF12 antibody have revealed that it is essential in neural crest development, craniofacial morphogenesis, and myogenesis. Mutations in the TCF12 gene cause craniosynostosis, a disorder characterized by premature fusion of cranial sutures. This highlights the importance of Transcription factor 12 in skeletal and craniofacial development. Its broad role in embryonic patterning underscores its significance in developmental biology.

In cancer research, dysregulation of TCF12 contributes to oncogenesis. Research using TCF12 antibody has shown that aberrant expression promotes epithelial-mesenchymal transition, migration, and invasion in cancers such as glioblastoma and colorectal carcinoma. By altering transcriptional programs, TCF12 contributes to tumor progression and poor clinical outcomes.

Beyond cancer, TCF12 has been linked to immune function. Studies with TCF12 antibody have revealed that it regulates lymphocyte development and differentiation. By controlling gene expression in immune progenitors, Transcription factor 12 ensures proper immune cell lineage commitment and functional competence. This expands its relevance to immunology.

TCF12 antibody is widely applied in chromatin immunoprecipitation, western blotting, and immunohistochemistry. Chromatin immunoprecipitation identifies DNA targets, western blotting quantifies protein expression, and immunohistochemistry reveals nuclear localization in tissue. These approaches make TCF12 antibody a versatile tool in developmental and disease biology.

By supplying validated TCF12 antibody reagents, NSJ Bioreagents supports studies into transcriptional control, development, and pathology. Detection of Transcription factor 12 provides researchers with insight into how helix-loop-helix proteins regulate gene expression across diverse biological systems.

UniProt: Q99081

Pathways: SARS-CoV-2 Protein Interactome