Oncostatin M Receptor anticorps (AA 673-968)

N° du produit ABIN7876393

Cet anticorps anti-Oncostatin M Receptor Polyclonal Lapin (ABIN7876393) détecte spécifiquement Oncostatin M Receptor dans WB, ELISA et FACS. L’anticorps est réactif avec des échantillons de Souris et Rat.

Aperçu rapide pour Oncostatin M Receptor anticorps (AA 673-968) (ABIN7876393)

Antigène: Oncostatin M Receptor (OSMR)

Reactivité: Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Oncostatin M Receptor est non-conjugé

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS)

Détail du produit anti-Oncostatin M Receptor anticorps

Épitope: AA 673-968

Fonction: Osmr Antibody / Oncostatin M receptor

Purification: Immunogen affinity purified

Immunogène: E.coli-derived mouse Osmr recombinant protein (Position: E673-Q968) was used as the immunogen for the Osmr antibody.

Isotype: IgG

Information d'application

Indications d'application: Optimal dilution of the Osmr antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Stock: 4 °C,-20 °C

Stockage commentaire: After reconstitution, the Osmr antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Détails sur Oncostatin M Receptor

Antigène: Oncostatin M Receptor (OSMR)

Autre désignation: Osmr

Sujet: OSMR antibody detects Oncostatin M receptor, a cytokine receptor that forms part of the type I cytokine receptor family and mediates signaling by the cytokines oncostatin M and interleukin-31. OSMR dimerizes with either gp130 or IL31RA to initiate downstream JAK-STAT, MAPK, and PI3K signaling cascades. The OSMR antibody is widely used in immunology, inflammation, and cancer research to study cytokine signaling, tissue remodeling, and immune regulation.

OSMR is encoded by the OSMR gene on human chromosome 5p13.1. The protein is approximately 100 kilodaltons and contains an extracellular cytokine-binding domain, a single transmembrane helix, and a cytoplasmic tail harboring signaling motifs that recruit JAK kinases and STAT transcription factors. OSMR is expressed in a wide range of cell types, including epithelial cells, fibroblasts, and immune cells, where it mediates diverse biological responses to inflammatory cues.

An OSMR antibody detects a 100-200 kilodalton band by western blot and exhibits membrane and perinuclear staining under immunofluorescence. Ligand binding induces heterodimerization of OSMR with gp130 or IL31RA, leading to phosphorylation of JAK1 and JAK2 and subsequent activation of STAT3 and STAT5 transcription factors. These pathways regulate genes involved in cell proliferation, differentiation, and extracellular matrix remodeling.

In the immune system, OSMR signaling modulates macrophage activation, Th2 cytokine production, and inflammation resolution. In epithelial tissues, OSMR promotes wound healing and regeneration but, when overactivated, contributes to chronic inflammation and fibrosis. Dysregulation of OSMR expression has been linked to psoriasis, asthma, and several cancers, where it enhances tumor progression through paracrine cytokine signaling.

Because of its dual role in inflammation and tissue regeneration, OSMR represents an important biomarker and therapeutic target in immune-mediated and neoplastic diseases. NSJ Bioreagents provides a validated OSMR antibody optimized for its applications, supporting research into cytokine receptor signaling, inflammatory pathways, and cancer biology.

UniProt: O70458

Pathways: Signalistation JAK/STAT, Growth Factor Binding