Thyroperoxidase anticorps (AA 685-804)

N° du produit ABIN7876417

Cet anticorps anti-Thyroperoxidase Monoclonal Souris (Clone TPO-3700) (ABIN7876417) détecte spécifiquement Thyroperoxidase dans IHC (p). L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour Thyroperoxidase anticorps (AA 685-804) (ABIN7876417)

Antigène: Thyroperoxidase (TPO) (Thyroid Peroxidase (TPO))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Thyroperoxidase est non-conjugé

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: TPO-3700

Détail du produit anti-Thyroperoxidase anticorps

Épitope: AA 685-804

Fonction: Thyroid Peroxidase Antibody / TPO

Purification: Protein G affinity chromatography

Immunogène: A portion of amino acids 685-804 from the human protein was used as the immunogen for the Thyroid Peroxidase antibody.

Isotype: IgG1, kappa

Information d'application

Indications d'application: Optimal dilution of the Thyroid Peroxidase antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store the Thyroid Peroxidase antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Détails sur Thyroperoxidase

Antigène: Thyroperoxidase (TPO) (Thyroid Peroxidase (TPO))

Autre désignation: Thyroid Peroxidase

Sujet: Thyroperoxidase (TPO) is a 933 amino acid, type I transmembrane glycoprotein that plays a key role in thyroid gland function and autoimmunity. It is present as a dimer on the apical surface of thyroid follicular cells. TPO functions in the iodination of tyrosine residues in thyroglobulin and phenoxy-ester formation between pairs of iodinated tyrosines to generate the thyroid hormones, thyroxine and triiodothyronine. Mutations in this gene are associated with several disorders of thyroid hormonogenesis, including congenital hypothyroidism, congenital goiter, and thyroid hormone organification defect IIA. Malignant thyroid tumors exhibit an anomaly in TPO resulting in lower affinity for anti-TPO. This antibody may aid in the differentiation between benign and malignant thyroid tumors.

UniProt: P07202

Pathways: Thyroid Hormone Synthesis