Recombinant Thyroperoxidase anticorps (AA 685-804)

N° du produit ABIN7876423

Cet anticorps anti-Thyroperoxidase Monoclonal Lapin (Clone TPO-6417R) (ABIN7876423) détecte spécifiquement Thyroperoxidase dans IHC (p). L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour Recombinant Thyroperoxidase anticorps (AA 685-804) (ABIN7876423)

Antigène: Thyroperoxidase (TPO) (Thyroid Peroxidase (TPO))

Type d'anticorp: Recombinant Antibody

Reactivité: Humain

Hôte: Lapin

Clonalité: Monoclonal

Conjugué: Cet anticorp Thyroperoxidase est non-conjugé

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: TPO-6417R

Détail du produit anti-Thyroperoxidase anticorps

Épitope: AA 685-804

Fonction: Recombinant TPO Antibody / Thyroid Peroxidase

Purification: Protein A/G affinity

Immunogène: A portion of amino acids 685-804 from the human protein was used as the immunogen for the recombinant TPO antibody.

Isotype: IgG

Information d'application

Indications d'application: Optimal dilution of the recombinant TPO antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles

Stock: -20 °C

Stockage commentaire: Aliquot the recombinant TPO antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Détails sur Thyroperoxidase

Antigène: Thyroperoxidase (TPO) (Thyroid Peroxidase (TPO))

Autre désignation: TPO

Sujet: Thyroperoxidase (TPO) is a 933 amino acid, type I transmembrane glycoprotein that plays a key role in thyroid gland function and autoimmunity. It is present as a dimer on the apical surface of thyroid follicular cells. TPO functions in the iodination of tyrosine residues in thyroglobulin and phenoxy-ester formation between pairs of iodinated tyrosines to generate the thyroid hormones, thyroxine and triiodothyronine. Mutations in this gene are associated with several disorders of thyroid hormonogenesis, including congenital hypothyroidism, congenital goiter, and thyroid hormone organification defect IIA.Malignant thyroid tumors exhibit an anomaly in TPO resulting in lower affinity for anti-TPO. This antibody may aid in the differentiation between benign and malignant thyroid tumors.

UniProt: P07202

Pathways: Thyroid Hormone Synthesis