KAP1 anticorps (AA 699-835)

N° du produit ABIN7876462

Cet anticorps anti-KAP1 Monoclonal Souris (Clone 3H2) (ABIN7876462) détecte spécifiquement KAP1 dans WB, IF, FACS, IHC (p) et IHC (fro). L’anticorps est réactif avec des échantillons de Humain, Souris et Rat.

Aperçu rapide pour KAP1 anticorps (AA 699-835) (ABIN7876462)

Antigène: KAP1 (TRIM28) (Tripartite Motif Containing 28 (TRIM28))

Reactivité: Humain, Souris, Rat

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp KAP1 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Clone: 3H2

Détail du produit anti-KAP1 anticorps

Épitope: AA 699-835

Fonction: TRIM28 Antibody / KAP1

Purification: Affinity purified

Immunogène: Recombinant human protein (amino acids A699-P835) was used as the immunogen for the TRIM28 antibody.

Isotype: IgG2b

Information d'application

Indications d'application: Optimal dilution of the TRIM28 antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Stock: 4 °C,-20 °C

Stockage commentaire: After reconstitution, the TRIM28 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Détails sur KAP1

Antigène: KAP1 (TRIM28) (Tripartite Motif Containing 28 (TRIM28))

Autre désignation: TRIM28

Sujet: Tripartite motif-containing 28 (TRIM28), also known as transcriptional intermediary factor 1 beta (TIF1b) and KAP1 (KRAB-associated protein-1), is a protein that in humans is encoded by the TRIM28 gene. The protein encoded by this gene mediates transcriptional control by interaction with the Kruppel-associated box repression domain found in many transcription factors. The protein localizes to the nucleus and is thought to associate with specific chromatin regions. KAP1 is a ubiquitously expressed protein involved in many critical functions including: transcriptional regulation, cellular differentiation and proliferation, DNA damage repair, viral suppression, and apoptosis. Its functionality is dependent upon post-translational modifications. Phosphorylation of KAP1 acts as a deactivator of the protein in many of its mechanisms while sumoylation acts as an activator.

UniProt: Q13263

Pathways: Signalisation Hedgehog, Positive Regulation of Response to DNA Damage Stimulus