Neuropilin 1 anticorps (AA 700-900)

N° du produit ABIN7876552

Cet anticorps anti-Neuropilin 1 Monoclonal Souris (Clone NRP1-4620) (ABIN7876552) détecte spécifiquement Neuropilin 1 dans IHC (p). L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour Neuropilin 1 anticorps (AA 700-900) (ABIN7876552)

Antigène: Neuropilin 1 (NRP1)

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Neuropilin 1 est non-conjugé

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: NRP1-4620

Détail du produit anti-Neuropilin 1 anticorps

Épitope: AA 700-900

Fonction: Neuropilin-1 Antibody

Purification: Protein A/G affinity

Immunogène: A recombinant partial protein (within amino acids 700-900) from the human protein was used as the immunogen for the Neuropilin-1 antibody.

Isotype: IgG1, kappa

Information d'application

Indications d'application: Optimal dilution of the Neuropilin-1 antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Aliquot the Neuropilin-1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Détails sur Neuropilin 1

Antigène: Neuropilin 1 (NRP1)

Autre désignation: Neuropilin-1

Sujet: Neuropilin is a type I transmembrane receptor that has been implicated in aspects of axon growth and guidance and has been shown to act as a high affinity receptor for class III semaphorins and vascular endothelial growth factor (VEGF). A closely related protein, neuropilin-2, shares a common domain structure and signifcant homology with neuropilin and also acts as a receptor for the class III semaphorins and VEGF. Both neuropilins are involved in regulating many physiological pathways including axonal guidance and angiogenesis, however they exhibit differential expression in the adult vasculature. Neuropilin-2 is polysialylated and expressed on the surface of dendritic cells. It is also expressed by venous and lymphatic endothelium. Neuropilin is expressed predominantly by arterial endothelium.

UniProt: O14786

Pathways: Regulation of Cell Size, Signaling Events mediated by VEGFR1 and VEGFR2, Smooth Muscle Cell Migration, Platelet-derived growth Factor Receptor Signaling, VEGFR1 Specific Signals