Geminin anticorps (AA 71-202)

N° du produit ABIN7876600

Cet anticorps anti-Geminin Monoclonal Souris (Clone GMNN-4033) (ABIN7876600) détecte spécifiquement Geminin dans IHC (p). L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour Geminin anticorps (AA 71-202) (ABIN7876600)

Antigène: Geminin (GMNN) (Geminin, DNA Replication Inhibitor (GMNN))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Geminin est non-conjugé

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Classe de qualité: Carrier-free

Clone: GMNN-4033

Détail du produit anti-Geminin anticorps

Épitope: AA 71-202

Fonction: GMNN Antibody / Geminin (azide and preservative free)

Purification: Protein A/G affinity

Immunogène: A portion of amino acids 71-202 was used as the immunogen for the GMNN antibody.

Isotype: IgG1, kappa

Information d'application

Indications d'application: Optimal dilution of the GMNN antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Agent conservateur: Azide free

Stock: -20 °C

Stockage commentaire: Aliquot the GMNN antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Détails sur Geminin

Antigène: Geminin (GMNN) (Geminin, DNA Replication Inhibitor (GMNN))

Autre désignation: GMNN

Sujet: Geminin is a nuclear protein that regulates the initiation of DNA replication during the cell cycle. DNA replication requires the coordinated association of Cdc6 and minichromosome maintenance (MCM) proteins with chromatin. Geminin blocks this assembly of the MCM into the prereplication complex and, in turn, prevents replication from occurring. Expression of Geminin fluctuates throughout the cell cycle with Geminin levels lowest at G1. Throughout S, G2 and M phases, Geminin levels are consistently elevated followed by a decrease during mitosis. The initiation of DNA replication is dependent on the degradation of Geminin during mitosis and the absence of Geminin throughout G1 phase. Geminin degradation is mediated by the anaphase-promoting complex (APC), which specifically targets B-type cyclins and other proteins containing a destruction box motif for degradation by ubiquitin-mediated proteolysis. While geminin expression is essential in maintaining chromosomal integrity, it is frequently overexpressed in cancers and evidence suggests that it plays a significant role in tumor proliferation and progression.

UniProt: O75496

Pathways: EGFR Signaling Pathway, DNA Replication