REPS2 anticorps (AA 76-564)

N° du produit ABIN7876750

Cet anticorps anti-REPS2 Polyclonal Lapin (ABIN7876750) détecte spécifiquement REPS2 dans WB et ELISA. L’anticorps est réactif avec des échantillons de Souris et Rat.

Aperçu rapide pour REPS2 anticorps (AA 76-564) (ABIN7876750)

Antigène: REPS2 (RALBP1 Associated Eps Domain Containing Protein 2 (REPS2))

Reactivité: Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp REPS2 est non-conjugé

Application: Western Blotting (WB), ELISA

Détail du produit anti-REPS2 anticorps

Épitope: AA 76-564

Fonction: REPS2 Antibody / RalBP1-associated Eps domain-containing protein 2

Purification: Immunogen affinity purified

Immunogène: E.coli-derived human REPS2 recombinant protein (Position: A76-K564) was used as the immunogen for the REPS2 antibody.

Isotype: IgG

Information d'application

Indications d'application: Optimal dilution of the REPS2 antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Stock: 4 °C,-20 °C

Stockage commentaire: After reconstitution, the REPS2 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Détails sur REPS2

Antigène: REPS2 (RALBP1 Associated Eps Domain Containing Protein 2 (REPS2))

Autre désignation: REPS2

Sujet: REPS2 antibody detects RalBP1-associated Eps domain-containing protein 2, a signaling adaptor that mediates endocytosis and receptor trafficking. The UniProt recommended name is RalBP1-associated Eps domain-containing protein 2 (REPS2). This cytoplasmic protein functions in clathrin-mediated endocytosis, growth factor receptor internalization, and signal transduction downstream of small GTPases such as RalA and RalB.

Functionally, REPS2 antibody identifies a 639-amino-acid protein containing EH (Eps15 homology) domains that mediate interactions with endocytic machinery proteins including Eps15, RalBP1, and AP-2. REPS2 contributes to the internalization of epidermal growth factor receptor (EGFR) and other tyrosine kinase receptors, influencing receptor recycling and downregulation. It also participates in the regulation of cytoskeletal dynamics and cell adhesion through Ral GTPase-dependent pathways.

The REPS2 gene is located on chromosome Xp22.3 and is expressed in epithelial tissues, neurons, and endocrine glands. In addition to its role in endocytosis, REPS2 modulates insulin signaling, exocytosis, and vesicular trafficking, providing a link between receptor activation and intracellular transport systems.

Pathologically, aberrant REPS2 expression has been implicated in prostate cancer, breast cancer, and neurological disorders. Overexpression promotes cancer cell migration and survival by sustaining receptor tyrosine kinase signaling, while loss of REPS2 can impair receptor internalization and lead to altered growth factor responsiveness. Research using REPS2 antibody supports studies in membrane trafficking, cell signaling, and tumor progression.

REPS2 antibody is validated for western blotting, immunofluorescence, and immunohistochemistry to detect endocytic adaptor proteins. NSJ Bioreagents provides REPS2 antibody reagents optimized for studies in receptor trafficking, cytoskeletal regulation, and cancer biology.

Structurally, RalBP1-associated Eps domain-containing protein 2 contains N-terminal EH domains, central coiled-coil motifs, and proline-rich regions that mediate protein-protein interactions. These domains form scaffolds for complex assembly with signaling and endocytic components. This antibody enables the analysis of REPS2's role in receptor-mediated endocytosis and signaling modulation.

UniProt: Q8NFH8

Pathways: EGFR Signaling Pathway