TRIM24 anticorps (AA 789-843)

N° du produit ABIN7876792

Cet anticorps anti-TRIM24 Polyclonal Lapin (ABIN7876792) détecte spécifiquement TRIM24 dans WB, IF et IHC (p). L’anticorps est réactif avec des échantillons de Souris.

Aperçu rapide pour TRIM24 anticorps (AA 789-843) (ABIN7876792)

Antigène: TRIM24 (Tripartite Motif Containing 24 (TRIM24))

Reactivité: Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TRIM24 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Détail du produit anti-TRIM24 anticorps

Épitope: AA 789-843

Fonction: Trim24 Antibody / Tif1 alpha / Tif1a

Purification: Antigen affinity purified

Immunogène: A portion of amino acids 789-843 from the mouse protein was used as the immunogen for the Trim24 antibody.

Isotype: Ig Fraction

Information d'application

Indications d'application: The stated application concentrations are suggested starting points. Titration of the Trim24 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Aliquot the Trim24 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Détails sur TRIM24

Antigène: TRIM24 (Tripartite Motif Containing 24 (TRIM24))

Autre désignation: Trim24

Sujet: Transcriptional coactivator that interacts with numerous nuclear receptors and coactivators and modulates the transcription of target genes. Interacts with chromatin depending on histone H3 modifications, having the highest affinity for histone H3 that is both unmodified at 'Lys-4' (H3K4me0) and acetylated at 'Lys-23' (H3K23ac) (By similarity). Has E3 protein-ubiquitin ligase activity. Promotes ubiquitination and proteasomal degradation of p53/TP53. Plays a role in the regulation of cell proliferation and apoptosis via its effects on p53/TP53 levels. Up-regulates ligand- dependent transcription activation by AR, GCR/NR3C1, thyroid hormone receptor (TR) and ESR1. Modulates transcription activation by retinoic acid (RA) receptors, such as RARA. Plays a role in regulating retinoic acid-dependent proliferation of hepatocytes. Required for normal transition from proliferating neonatal hepatocytes to quiescent adult hepatocytes.

UniProt: Q64127