CPS1 anticorps (AA 800-100)

N° du produit ABIN7876864

Cet anticorps anti-CPS1 Monoclonal Souris (Clone CPS1-9869) (ABIN7876864) détecte spécifiquement CPS1 dans WB et IHC (p). L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour CPS1 anticorps (AA 800-100) (ABIN7876864)

Antigène: CPS1 (Carbamoyl-Phosphate Synthase 1, Mitochondrial (CPS1))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp CPS1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Classe de qualité: Carrier-free

Clone: CPS1-9869

Détail du produit anti-CPS1 anticorps

Épitope: AA 800-100

Fonction: CPSase I Antibody / Carbamoyl phosphate synthetase 1 / CPS1 (azide and preservative free)

Purification: Protein A/G affinity

Immunogène: A portion of amino acids 800-100 from human CPS1 protein was used as the immunogen for the CPSase I antibody.

Isotype: IgG, kappa

Information d'application

Indications d'application: Optimal dilution of the CPSase I antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Agent conservateur: Azide free

Stock: -20 °C

Stockage commentaire: Aliquot the CPSase I antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Détails sur CPS1

Antigène: CPS1 (Carbamoyl-Phosphate Synthase 1, Mitochondrial (CPS1))

Autre désignation: CPSase I

Sujet: This MAb recognizes a protein of 165 kDa, identified as carbamoyl phosphate synthetase 1 (CPS1). This mitochondrial enzyme catalyzes synthesis of carbamoyl phosphate from ammonia and bicarbonate. This reaction is the first committed step of the urea cycle, which is important in the removal of excess urea from cells. Deficiency of CPS1 is an autosomal recessive disorder that causes hyperammonemia. CPS1 is a hepatocyte specific protein that localizes to the mitochondria of hepatocytes. It is a sensitive marker for distinguishing hepatocellular carcinomas (HCC) from other metastatic carcinomas as well as cholangio-carcinomas. HCC s occur primarily in the stomach, but they are also found in many other organs. CPS1 may also be a useful marker for intestinal metaplasia. Reportedly, strong expression of CPS1 correlates with smaller tumor size and longer patient survival. Occasionally, CPS1 is also found in gastric carcinomas as well as in a few other non-hepatic tumors.

UniProt: P31327

Pathways: Response to Growth Hormone Stimulus, Cellular Glucan Metabolic Process