Ube2t anticorps (AA 9-145)

N° du produit ABIN7877065

Cet anticorps anti-Ube2t Polyclonal Lapin (ABIN7877065) détecte spécifiquement Ube2t dans WB, ELISA, IF et FACS. L’anticorps est réactif avec des échantillons de Humain, Souris et Rat.

Aperçu rapide pour Ube2t anticorps (AA 9-145) (ABIN7877065)

Antigène: Ube2t (Ubiquitin-Conjugating Enzyme E2T (Ube2t))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Ube2t est non-conjugé

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Flow Cytometry (FACS)

Détail du produit anti-Ube2t anticorps

Épitope: AA 9-145

Fonction: UBE2T Antibody / Ubiquitin-conjugating enzyme E2 T / HSPC150

Purification: Immunogen affinity purified

Immunogène: E.coli-derived human UBE2T recombinant protein (Position: R9-Q145) was used as the immunogen for the UBE2T antibody.

Isotype: IgG

Information d'application

Indications d'application: Optimal dilution of the UBE2T antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Stock: 4 °C,-20 °C

Stockage commentaire: After reconstitution, the UBE2T antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Détails sur Ube2t

Antigène: Ube2t (Ubiquitin-Conjugating Enzyme E2T (Ube2t))

Autre désignation: UBE2T

Sujet: UBE2T antibody detects Ubiquitin-conjugating enzyme E2 T, encoded by the UBE2T gene. Ubiquitin-conjugating enzyme E2 T is a member of the E2 family of enzymes that catalyze the transfer of ubiquitin to target proteins, particularly in the context of the Fanconi anemia DNA repair pathway. UBE2T antibody provides researchers with a critical reagent for studying ubiquitin signaling, DNA repair, and cancer.

Ubiquitin-conjugating enzyme E2 T functions as the cognate E2 for FANCL, the E3 ligase of the Fanconi anemia core complex. Research using UBE2T antibody has shown that it is required for monoubiquitination of FANCD2 and FANCI, a critical step in the repair of DNA interstrand crosslinks. This activity ensures faithful DNA replication and genome stability.

Studies with UBE2T antibody have revealed that loss of UBE2T function causes Fanconi anemia, a rare genetic disorder characterized by bone marrow failure, congenital abnormalities, and cancer predisposition. Patient mutations in UBE2T impair its ubiquitin conjugating activity, preventing activation of FANCD2 and disrupting DNA repair. These findings emphasize the clinical importance of UBE2T in genome maintenance.

Beyond Fanconi anemia, dysregulation of Ubiquitin-conjugating enzyme E2 T has been associated with cancer progression. Research using UBE2T antibody has shown that overexpression promotes proliferation, survival, and resistance to DNA-damaging therapies in breast, lung, and liver cancers. This suggests potential as both a biomarker and therapeutic target.

UBE2T antibody is widely applied in western blotting, immunohistochemistry, and functional repair assays. Western blotting detects monoubiquitination of FANCD2, immunohistochemistry demonstrates tumor-associated expression, and repair assays confirm participation in crosslink repair. These applications make UBE2T antibody indispensable in DNA repair and cancer biology.

By providing validated UBE2T antibody reagents, NSJ Bioreagents supports studies into ubiquitination, DNA repair, and disease. Detection of Ubiquitin-conjugating enzyme E2 T provides researchers with insight into how ubiquitin pathways regulate genome stability and cancer progression.

UniProt: Q9NPD8

Pathways: Chromatin Binding