SOX10 anticorps (AA 90-179)

N° du produit ABIN7877101

Cet anticorps anti-SOX10 Monoclonal Souris (Clone PCRP-SOX10-1D8) (ABIN7877101) détecte spécifiquement SOX10 dans IF et FACS. L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour SOX10 anticorps (AA 90-179) (ABIN7877101)

Antigène: SOX10 (SRY (Sex Determining Region Y)-Box 10 (SOX10))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp SOX10 est non-conjugé

Application: Immunofluorescence (IF), Flow Cytometry (FACS)

Classe de qualité: Carrier-free

Clone: PCRP-SOX10-1D8

Détail du produit anti-SOX10 anticorps

Épitope: AA 90-179

Fonction: SOX10 Antibody (azide and preservative free)

Purification: Protein A/G affinity

Immunogène: A portion of amino acids 90-179 was used as the immunogen for the SOX10 antibody.

Isotype: IgG2b

Information d'application

Indications d'application: Optimal dilution of the SOX10 antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Agent conservateur: Azide free

Stock: -20 °C

Stockage commentaire: Aliquot the SOX10 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Détails sur SOX10

Antigène: SOX10 (SRY (Sex Determining Region Y)-Box 10 (SOX10))

Autre désignation: SOX10

Sujet: This MAb is highly specific and does not cross-react with other members of the SOX-family. SOX genes comprise a family of genes that are related to the mammalian sex-determining gene SRY. These genes similarly contain sequences that encode for the HMG-box domain, which is responsible for the sequence-specific DNA-binding activity. SOX10 is a sensitive marker of melanoma, including conventional, spindled, and desmoplastic subtypes. Expressed by metastatic melanomas and nodal capsular nevus in sentinel lymph nodes, but not by other lymph node components such as dendritic cells, which usually express S100 protein. Often used melanoma markers, such as anti-HMB45 and anti-MelanA, are poorly expressed in desmoplastic melanomas while SOX10 is moderately-to-strongly expressed in desmoplastic melanomas.

UniProt: P56693

Pathways: Chromatin Binding