WDR55 anticorps (C-Term)

N° du produit ABIN7877499

L’anticorps anti-WDR55 Polyclonal Lapin est utilisé pour la détection de WDR55 dans des échantillons de Humain et Souris. Il a été validé pour WB et FACS.

Aperçu rapide pour WDR55 anticorps (C-Term) (ABIN7877499)

Antigène: WDR55 (WD Repeat Domain 55 (WDR55))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp WDR55 est non-conjugé

Application: Western Blotting (WB), Flow Cytometry (FACS)

Détail du produit anti-WDR55 anticorps

Épitope: C-Term

Fonction: WDR55 Antibody / WD repeat-containing protein 55

Purification: Immunogen affinity purified

Immunogène: A synthetic peptide corresponding to a sequence at the C-terminus of human WDR55 was used as the immunogen for the WDR55 antibody.

Isotype: IgG

Information d'application

Indications d'application: Optimal dilution of the WDR55 antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Stock: 4 °C,-20 °C

Stockage commentaire: After reconstitution, the WDR55 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Détails sur WDR55

Antigène: WDR55 (WD Repeat Domain 55 (WDR55))

Autre désignation: WDR55

Sujet: WDR55 antibody detects WD repeat-containing protein 55, a nucleolar protein essential for ribosome biogenesis and cell proliferation. The UniProt recommended name is WD repeat-containing protein 55 (WDR55). This protein participates in the maturation of 18S ribosomal RNA and assembly of the small ribosomal subunit, contributing to efficient protein synthesis and cell growth.

Functionally, WDR55 antibody identifies a 365-amino-acid protein that localizes to the nucleolus, where it interacts with components of the small subunit (SSU) processome. WDR55's WD-repeat domains form beta-propeller structures that scaffold RNA processing enzymes and ribonucleoprotein complexes necessary for pre-rRNA cleavage and modification.

The WDR55 gene is located on chromosome 2q23.3 and is expressed in actively dividing tissues, including testis, thymus, and embryonic stem cells. By regulating ribosome biogenesis, WDR55 supports developmental processes requiring high translational output and cell proliferation.

Pathologically, loss of WDR55 function disrupts rRNA processing and nucleolar organization, leading to developmental delay, craniofacial abnormalities, and immunodeficiency (as seen in North American Indian childhood cirrhosis-like syndromes). Research using WDR55 antibody supports studies in ribosome assembly, RNA biology, and developmental genetics.

WDR55 antibody is validated for western blotting, immunofluorescence, and immunohistochemistry to detect nucleolar proteins and ribosome assembly factors. NSJ Bioreagents provides WDR55 antibody reagents optimized for studies in RNA metabolism, cell cycle regulation, and nucleolar dynamics.

Structurally, WD repeat-containing protein 55 contains multiple WD repeats forming a propeller-like fold that mediates stable RNA-protein interactions. This antibody enables investigation of WDR55's role in ribosome biogenesis and nucleolar organization.

UniProt: Q9H6Y2