FAT1 anticorps (Cytoplasmic Domain)

N° du produit ABIN7877531

Cet anticorps Souris Monoclonal détecte spécifiquement FAT1 dans ELISA, WB et IF. Il présente une réactivité avec des échantillons de Drosophila melanogaster.

Aperçu rapide pour FAT1 anticorps (Cytoplasmic Domain) (ABIN7877531)

Antigène: FAT1 (FAT Tumor Suppressor Homolog 1 (FAT1))

Reactivité: Drosophila melanogaster

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp FAT1 est non-conjugé

Application: ELISA, Western Blotting (WB), Immunofluorescence (IF)

Classe de qualité: Carrier-free

Clone: FAT1-3D7-1

Détail du produit anti-FAT1 anticorps

Épitope: Cytoplasmic Domain

Fonction: FAT1 Antibody (Drosophila melanogaster) (azide and preservative free)

Purification: PEG precipitation

Immunogène: The cytoplasmic domain of Drosophila Fat protein was used as the immunogen for the FAT1 antibody.

Isotype: IgM, kappa

Information d'application

Indications d'application: Optimal dilution of the FAT1 antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Agent conservateur: Azide free

Stock: 4 °C,-20 °C

Stockage commentaire: Store the FAT1 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Détails sur FAT1

Antigène: FAT1 (FAT Tumor Suppressor Homolog 1 (FAT1))

Autre désignation: FAT1

Sujet: The FAT proteins are members of the Cadherin superfamily homologous to the Drosophila Fat protein that functions as a positive regulator of planar cell polarity in the Drosophila wing. FAT1 is an unusual cadherin that controls cell growth and planar polarity while acting as a tumor suppressor. FAT1 is a proximal element of a signaling pathway that determines both cellular polarity in the plane of the monolayer and directed actin-dependent cell motility. FAT1 is localized at the leading edge of lamellipodia, filopodia and microspike tips where it directly interacts with Ena/VASP proteins to regulate the actin polymerization complex. When targeted to mitochondrial outer leaflets, the cytoplasmic domain of FAT1 recruits components of the actin polymerization machinery sufficient to induce ectopic actin polymerization. FAT1 expression in vascular smooth muscle cells (VSMCs) increases significantly after arterial injury or growth factor stimulation, implicating FAT1 in the control of VSMC functions central to vascular remodeling by facilitating migration and limiting proliferation. FAT1 is also involved in psychic disorders, and its action may be of patho-physiological importance.

UniProt: Q14517