Cet anticorps Souris Monoclonal détecte spécifiquement Annexin a1 dans WB, FACS, IF et IHC (p). Il présente une réactivité avec des échantillons de Humain.
Optimal dilution of the Annexin A1 antibody should be determined by the researcher.
Restrictions
For Research Use only
Format
Liquid
Concentration
1 mg/mL
Buffer
1 mg/mL in 1X PBS, BSA free, sodium azide free
Agent conservateur
Azide free
Stock
4 °C,-20 °C
Stockage commentaire
Store the Annexin A1 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Antigène
Annexin a1 (ANXA1)
(Annexin A1 (ANXA1))
Autre désignation
Annexin A1
Sujet
The ANXA1 gene belongs to the annexin family, and contains 4 annexin repeats. A pair of annexin repeats may form one binding site for calcium and a phospholipid. ANXA1 promotes membrane fusion and is involved in exocytosis. The gene for ANXA1 is upregulated in hairy cell leukemia (HCL), and its protein expression is specific for HCL. Detection of ANXA1 provides a simple, highly sensitive and specific assay for diagnosing HCL. Annexin A1 has also been found to be protective against DNA damage induced by heat in breast cancer cells, suggesting it is involved in tumor suppressive and protective activities, and also is associated with treatment resistance.