Calcineurin B anticorps (full length)

N° du produit ABIN7877754

L’anticorps anti-Calcineurin B Monoclonal Souris est utilisé pour la détection de Calcineurin B dans des échantillons de Humain. Il a été validé pour WB et IHC (p).

Aperçu rapide pour Calcineurin B anticorps (full length) (ABIN7877754)

Antigène: Calcineurin B (CAN)

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Calcineurin B est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: BE2-1

Détail du produit anti-Calcineurin B anticorps

Épitope: full length

Fonction: Calcineurin B Antibody / PPP3R1

Purification: Protein G affinity chromatography

Immunogène: A recombinant full-length human Calcineurin B protein was used as the immunogen for the Calcineurin B antibody.

Isotype: IgG2a, kappa

Information d'application

Indications d'application: Optimal dilution of the Calcineurin B antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store the Calcineurin B antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Détails sur Calcineurin B

Antigène: Calcineurin B (CAN)

Autre désignation: Calcineurin B

Sujet: Calcineurin is an enzyme that dephosphorylates serine and threonine residues in proteins. It is a heterodimer of a 59 kDa catalytic A subunit and a 19 kDa regulatory B subunit that is activated by the binding of calcium ions and calmodulin. Calcineurin is expressed in many tissues, but its levels are highest in the brain, where it may play a role in learning and memory. It has many substrates, including NFAT, a transcription factor that is activated by dephosphorylation. Complexes of the immuno-suppressants cyclosporine and FK506 with immunophilin proteins such as cyclophilin and FKBP12 are potent and specific inhibitors of Calcineurin activity. Alterations in Calcineurin activity are suspected to play a role in cardiac hypertrophy and graft versus host disease in organ transplantation.

UniProt: P63098

Pathways: Cellular Glucan Metabolic Process, VEGF Signaling