Calpain anticorps (full length)

N° du produit ABIN7877759

Cet anticorps Souris Monoclonal détecte spécifiquement Calpain dans IHC (p). Il présente une réactivité avec des échantillons de Humain.

Aperçu rapide pour Calpain anticorps (full length) (ABIN7877759)

Antigène: Calpain

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Calpain est non-conjugé

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Classe de qualité: Carrier-free

Clone: CAPN1-1530

Détail du produit anti-Calpain anticorps

Épitope: full length

Fonction: Calpain Antibody / CAPN1 (azide and preservative free)

Purification: Protein G affinity chromatography

Immunogène: A recombinant full-length human CAPN1 protein was used as the immunogen for this Calpain antibody.

Isotype: IgG1, kappa

Information d'application

Indications d'application: Optimal dilution of the Calpain antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Agent conservateur: Azide free

Stock: 4 °C,-20 °C

Stockage commentaire: Store the Calpain antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Détails sur Calpain

Antigène: Calpain

Sujet: Calpain 1 is an intracellular calcium-dependent protease that cleaves cytoskeletal and sub-membranous proteins. Calpains are non-lysosomal, calcium-activated intracellular cysteine proteases. Calpains mediate specific Ca2+- dependent processes including cell fusion, mitosis and meiosis. Calpains are heterodimers of a small regulatory subunit and one of three large catalytic subunits, designated Calpain 1, Calpain 2 and Calpain p94. Calpastatin regulates Calpain by inhibiting both the proteolytic activity of Calpain and its binding to membranes. Calpastatin exists in two types, tissue type and erythrocyte type, resulting from both alternative splicing and proteolytic processing. Calpain 1 co-localizes with human leukocyte antigen-DR (HLA-DR) on activated microglia in the aging brain. Calpain influences the process of spermatogenesis and the events preceding fertilization, such as the acrosome reaction.

UniProt: P07384