Calpain anticorps (full length)

N° du produit ABIN7877760

L’anticorps anti-Calpain Monoclonal Souris est utilisé pour la détection de Calpain dans des échantillons de Humain. Il a été validé pour IHC (p).

Aperçu rapide pour Calpain anticorps (full length) (ABIN7877760)

Antigène: Calpain

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Calpain est non-conjugé

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: CAPN1-1530

Détail du produit anti-Calpain anticorps

Épitope: full length

Fonction: Calpain Antibody / CAPN1

Purification: Protein G affinity chromatography

Immunogène: A recombinant full-length human CAPN1 protein was used as the immunogen for this Calpain antibody.

Isotype: IgG1, kappa

Information d'application

Indications d'application: Optimal dilution of the Calpain antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store the Calpain antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Détails sur Calpain

Antigène: Calpain

Sujet: Calpain 1 is an intracellular calcium-dependent protease that cleaves cytoskeletal and sub-membranous proteins. Calpains are non-lysosomal, calcium-activated intracellular cysteine proteases. Calpains mediate specific Ca2+- dependent processes including cell fusion, mitosis and meiosis. Calpains are heterodimers of a small regulatory subunit and one of three large catalytic subunits, designated Calpain 1, Calpain 2 and Calpain p94. Calpastatin regulates Calpain by inhibiting both the proteolytic activity of Calpain and its binding to membranes. Calpastatin exists in two types, tissue type and erythrocyte type, resulting from both alternative splicing and proteolytic processing. Calpain 1 co-localizes with human leukocyte antigen-DR (HLA-DR) on activated microglia in the aging brain. Calpain influences the process of spermatogenesis and the events preceding fertilization, such as the acrosome reaction.

UniProt: P07384