Recombinant CD40 anticorps (full length)

N° du produit ABIN7877883

L’anticorps anti-CD40 Monoclonal Lapin est utilisé pour la détection de CD40 dans des échantillons de Humain. Il a été validé pour IHC (p).

Aperçu rapide pour Recombinant CD40 anticorps (full length) (ABIN7877883)

Antigène: CD40

Type d'anticorp: Recombinant Antibody

Reactivité: Humain

Hôte: Lapin

Clonalité: Monoclonal

Conjugué: Cet anticorp CD40 est non-conjugé

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Classe de qualité: Carrier-free

Clone: C40-9225R

Détail du produit anti-CD40 anticorps

Épitope: full length

Fonction: Recombinant CD40 Antibody (azide and preservative free)

Purification: Protein A/G affinity

Immunogène: Recombinant full-length human CD40 protein was used as the immunogen for the recombinant CD40 antibody.

Isotype: IgG1, kappa

Information d'application

Indications d'application: Optimal dilution of the recombinant CD40 antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Agent conservateur: Azide free

Stock: -20 °C

Stockage commentaire: Aliquot the recombinant CD40 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Détails sur CD40

Antigène: CD40

Autre désignation: CD40

Sujet: CD40 is a receptor on antigen-presenting cells of the immune system and is essential for mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction. The interaction of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. CD40 is expressed on B-lymphocytes, follicular dendritic cells, bone marrow-derived dendritic cells, thymic epithelium, and interdigitating cells in the T-cell zones of secondary lymphoid organs.

UniProt: P25942

Pathways: Signalisation NF-kappaB, Cellular Response to Molecule of Bacterial Origin, M Phase, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Cancer Immune Checkpoints