Recombinant CD59 anticorps (full length)

N° du produit ABIN7877931

L’anticorps anti-CD59 Monoclonal Souris est utilisé pour la détection de CD59 dans des échantillons de Humain. Il a été validé pour IHC (p).

Aperçu rapide pour Recombinant CD59 anticorps (full length) (ABIN7877931)

Antigène: CD59

Type d'anticorp: Recombinant Antibody

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp CD59 est non-conjugé

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: RMACIF-7288

Détail du produit anti-CD59 anticorps

Épitope: full length

Fonction: Recombinant CD59 Antibody

Purification: Protein A affinity

Immunogène: Recombinant human full-length CD59 protein was used as the immunogen for the recombinant CD59 antibody.

Isotype: IgG1, kappa

Information d'application

Indications d'application: Optimal dilution of the recombinant CD59 antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Aliquot the recombinant CD59 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Détails sur CD59

Antigène: CD59

Autre désignation: CD59

Sujet: Reacts with human CD59, a 20 kDa glycosyl phosphatidyl-inositol (GPI)-anchored cell surface protein (Workshop VI, Code N-L036). CD59 regulates complement-mediated cell lysis, and it is involved in lymphocyte signal transduction. This protein is a potent inhibitor of the complement membrane attack complex, whereby it binds complement C8 and/or C9 during the assembly of this complex, thereby inhibiting the incorporation of multiple copies of C9 into the complex, which is necessary for osmolytic pore formation. CD59 is widely distributed on cells in all tissues. It inhibits formation of MAC, thus protecting cells from complement-mediated lysis. The expression of CD59 on erythrocytes is important for their survival. Genetic defects in GPI-anchor attachment, that cause a reduction or loss of CD59 and CD55 on erythrocytes produce the symptoms of the disease paroxysmal hemoglobinuria (PNH). This MAb recognizes CD59 transfected cells. It is useful for study on GPI-anchored proteins, PNH and CD59 functions.

UniProt: P13987

Pathways: Système du Complément