Recombinant CD8 alpha anticorps (full length)

N° du produit ABIN7877959

Cet anticorps anti-CD8 alpha Monoclonal Lapin (Clone CD8-7793R) (ABIN7877959) détecte spécifiquement CD8 alpha dans IHC (p). L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour Recombinant CD8 alpha anticorps (full length) (ABIN7877959)

Antigène: CD8 alpha (CD8A) (CD8a Molecule (CD8A))

Type d'anticorp: Recombinant Antibody

Reactivité: Humain

Hôte: Lapin

Clonalité: Monoclonal

Conjugué: Cet anticorp CD8 alpha est non-conjugé

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Classe de qualité: Carrier-free

Clone: CD8-7793R

Détail du produit anti-CD8 alpha anticorps

Épitope: full length

Fonction: CD8A Antibody (azide and preservative free)

Purification: Protein A/G affinity

Immunogène: Recombinant human full-length CD8a protein was used as the immunogen for the CD8A antibody.

Isotype: IgG, kappa

Information d'application

Indications d'application: Optimal dilution of the CD8A antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Agent conservateur: Azide free

Stock: -20 °C

Stockage commentaire: Aliquot the CD8A antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Détails sur CD8 alpha

Antigène: CD8 alpha (CD8A) (CD8a Molecule (CD8A))

Autre désignation: CD8A

Sujet: This mAb is specific for the 32 kDa alpha chain of human CD8, known as CD8a or CD8 alpha. CD8 is a cell surface receptor expressed either as a heterodimer with the CD8 beta chain (CD8 alpha/beta) or as a homodimer (CD8 alpha/alpha). A majority of thymocytes and a subpopulation of mature T cells and NK cells express CD8a. CD8 binds to MHC class 1 and through its association with protein tyrosine kinase p56lck plays a role in T cell development and activation of mature T cells. For mature T-cells, CD4 and CD8 are mutually exclusive, so anti-CD8, generally used in conjunction with anti-CD4. It is a useful marker for distinguishing helper/inducer T-lymphocytes, and most peripheral T-cell lymphomas are CD4+/CD8-. Anaplastic large cell lymphoma is usually CD4+ and CD8-, and in T-lymphoblastic lymphoma/leukemia, CD4 and CD8 are often co-expressed. CD8 is also found in littoral cell angioma of the spleen.

UniProt: P01732

Pathways: TCR Signaling