Recombinant Complement C4d anticorps (full length)

N° du produit ABIN7877993

Cet anticorps Lapin Monoclonal détecte spécifiquement Complement C4d dans IHC (p). Il présente une réactivité avec des échantillons de Humain.

Aperçu rapide pour Recombinant Complement C4d anticorps (full length) (ABIN7877993)

Antigène: Complement C4d (C4d) (Complement Component C4d (C4d))

Type d'anticorp: Recombinant Antibody

Reactivité: Humain

Hôte: Lapin

Clonalité: Monoclonal

Conjugué: Cet anticorp Complement C4d est non-conjugé

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Classe de qualité: Carrier-free

Clone: C4D-9213R

Détail du produit anti-Complement C4d anticorps

Épitope: full length

Fonction: Recombinant Complement 4d Antibody / C4d (azide and preservative free)

Purification: Protein A/G affinity

Immunogène: Recombinant full-length human Complement 4d protein was used as the immunogen for the recombinant Complement 4d antibody.

Isotype: IgG, kappa

Information d'application

Indications d'application: Optimal dilution of the recombinant Complement 4d antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Agent conservateur: Azide free

Stock: 4 °C,-20 °C

Stockage commentaire: Aliquot the recombinant Complement 4d antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Détails sur Complement C4d

Antigène: Complement C4d (C4d) (Complement Component C4d (C4d))

Autre désignation: Complement 4d

Sujet: This MAb is specific to Complement 4d (C4d) and reacts with the secreted as well as cell-bound C4d. C4d is a degradation product of the activated complement factor C4b. Complement 4b is typically activated by binding of Abs to specific target molecules. Following activation and degradation of the C4 Molecule, thio-ester groups are exposed, which allow transient, covalent binding of the degradation product Complement 4d to endothelial cell surfaces and extracellular matrix components of vascular basement membranes near the sites of C4 activation. The presence of C4d in peritubular capillaries is a key indicator for acute humoral (i.e. antibody-mediated) rejection of kidney, heart, pancreas and lung allografts. As an established marker of antibody-mediated acute renal allograft rejection and its proclivity for endothelium, this component can be detected in peritubular capillaries in chronic renal allograft rejection as well as hyperacute rejection, acute vascular rejection, acute cellular rejection, and borderline rejection. It has been shown to be a significant predictor of transplant kidney graft survival. Anti-C4d, combined with anti-C3d, can be utilized as a tool for diagnosis of allograft rejection that may warrant a prompt and aggressive anti-rejection treatment.

UniProt: P0C0L4