Gelsolin anticorps (full length)

N° du produit ABIN7878274

Cet anticorps anti-Gelsolin Monoclonal Souris (Clone CPTC-Gelsolin-1) (ABIN7878274) détecte spécifiquement Gelsolin dans WB. L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour Gelsolin anticorps (full length) (ABIN7878274)

Antigène: Gelsolin (GSN)

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Gelsolin est non-conjugé

Application: Western Blotting (WB)

Classe de qualité: Carrier-free

Clone: CPTC-Gelsolin-1

Détail du produit anti-Gelsolin anticorps

Épitope: full length

Fonction: Gelsolin Antibody / GSN (azide and preservative free)

Purification: Protein G affinity chromatography

Immunogène: Recombinant human full-length protein was used as the immunogen for this Gelsolin antibody.

Isotype: IgG1, kappa

Information d'application

Indications d'application: Optimal dilution of the Gelsolin antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Agent conservateur: Azide free

Stock: 4 °C,-20 °C

Stockage commentaire: Store the Gelsolin antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Détails sur Gelsolin

Antigène: Gelsolin (GSN)

Autre désignation: Gelsolin

Sujet: Gelsolin (also known as brevin, Actin-depolymerizing factor or ADF), a proteinof leukocytes, platelets and other cells, severs Actin filaments in thepresence of submicromolar calcium, thereby isolating cytoplasmic Actin gels. It is a calcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping). It can promote the assembly of monomers into filaments (nucleation) as well as sever filaments already formed. Plays a role in ciliogenesis. Defects in GSN are the cause of amyloidosis type 5 (AMYL5), also known as familial amyloidosis Finnish type, typically characterized by cranial neuropathy and lattice corneal dystrophy. Severe systemic disease can develop in some individuals causing peripheral polyneuropathy, amyloid cardiomyopathy, and nephrotic syndrome leading to renal failure.

UniProt: P06396

Pathways: Caspase Cascade in Apoptosis, Regulation of Actin Filament Polymerization, Autophagy