IGFBP3 anticorps (full length)

N° du produit ABIN7878422

Cet anticorps Souris Monoclonal détecte spécifiquement IGFBP3 dans IHC (p). Il présente une réactivité avec des échantillons de Humain.

Aperçu rapide pour IGFBP3 anticorps (full length) (ABIN7878422)

Antigène: IGFBP3 (Insulin-Like Growth Factor Binding Protein 3 (IGFBP3))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp IGFBP3 est non-conjugé

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: IGFBP3-3423

Détail du produit anti-IGFBP3 anticorps

Épitope: full length

Fonction: Insulin-like growth factor-binding protein 3 Antibody / IGFBP3

Purification: Protein A/G affinity

Immunogène: Recombinant human full-length IGFBP3 protein was used as the immunogen for the Insulin-like growth factor-binding protein 3 antibody.

Isotype: IgG2b, kappa

Information d'application

Indications d'application: Optimal dilution of the Insulin-like growth factor-binding protein 3 antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Aliquot the Insulin-like growth factor-binding protein 3 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Détails sur IGFBP3

Antigène: IGFBP3 (Insulin-Like Growth Factor Binding Protein 3 (IGFBP3))

Autre désignation: Insulin-like growth factor-binding protein 3

Sujet: The Insulin-like growth factor-binding proteins, or IGFBPs, are a family of homologous proteins that have co-evolved with the IGFs. They serve not only as shuttle molecules for the soluble IGFs, but also confer a level of regulation to the IGF signaling system. Physical association of the IGFBPs with IGF influences the bio-availability of the growth factors, as well as their concentration and distribution in the extracellular environment. In addition, the IGFBPs appear to have biological activity independent of the IGFs. Seven IGFBPs have thus far been described, each differing in their tissue distribution, half-lives and modulation of IGF interactions with their receptors. IGFBP3 is the most abundant IGFBP and is complexed with roughly 80 % of the serum IGFs. Both IGFBP3 and IGFBP4 are released by dermal fibroblasts in response to incision injury.

UniProt: P17936

Pathways: Myometrial Relaxation and Contraction, Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development, Regulation of Carbohydrate Metabolic Process, Autophagy, Smooth Muscle Cell Migration, Growth Factor Binding