IRF3 anticorps (full length)

N° du produit ABIN7878448

Cet anticorps anti-IRF3 Monoclonal Souris (Clone PCRP-IRF3-4D7) (ABIN7878448) détecte spécifiquement IRF3 dans FACS et IHC (p). L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour IRF3 anticorps (full length) (ABIN7878448)

Antigène: IRF3 (Interferon Regulatory Factor 3 (IRF3))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp IRF3 est non-conjugé

Application: Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Classe de qualité: Carrier-free

Clone: PCRP-IRF3-4D7

Détail du produit anti-IRF3 anticorps

Épitope: full length

Fonction: Interferon regulatory factor 3 Antibody / IRF3 (azide and preservative free)

Purification: Protein A/G affinity

Immunogène: Recombinant full-length human IRF3 protein was used as the immunogen for the Interferon regulatory factor 3 antibody.

Isotype: IgG1

Information d'application

Indications d'application: Optimal dilution of the Interferon regulatory factor 3 antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Agent conservateur: Azide free

Stock: -20 °C

Stockage commentaire: Aliquot the Interferon regulatory factor 3 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Détails sur IRF3

Antigène: IRF3 (Interferon Regulatory Factor 3 (IRF3))

Autre désignation: Interferon regulatory factor 3

Sujet: Interferon regulatory factor-1 (IRF-1) and IRF-2 have been identified as novel DNA-binding factors that function as regulators of both type I interferon (interferon-Alpha and beta) and interferon-inducible genes. The two factors are structurally related, particularly in their N-terminal regions, which confer DNA binding specificity. In addition, both bind to the same sequence within the promoters of interferon-Alpha and interferon-beta genes. IRF-1 functions as an activator of interferon transcription, while IRF-2 binds to the same cis elements and represses IRF-1 action. IRF-1 and IRF-2 have been reported to act in a mutually antagonistic manner in regulating cell growth, overexpression of the repressor IRF-2 leads to cell transformation while concomitant overexpression of IRF-1 causes reversion. IRF-1 and IRF-2 are members of a larger family of DNA binding proteins that includes IRF-3, IRF-4, IRF-5, IRF-6, IRF-7, ISGF-3gammap48 and IFN consensus sequence-binding protein (ICSBP).

UniProt: Q14653

Pathways: Signalisation TLR, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Hepatitis C, Toll-Like Receptors Cascades