IL-4 anticorps (full length)

N° du produit ABIN7878459

L’anticorps anti-IL-4 Monoclonal Souris est utilisé pour la détection de IL-4 dans des échantillons de Humain. Il a été validé pour ELISA.

Aperçu rapide pour IL-4 anticorps (full length) (ABIN7878459)

Antigène: IL-4 (IL4) (Interleukin 4 (IL4))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp IL-4 est non-conjugé

Application: ELISA

Clone: IL4-1597

Détail du produit anti-IL-4 anticorps

Épitope: full length

Fonction: Interleukin 4 Antibody / IL-4

Purification: Protein G affinity chromatography

Immunogène: Recombinant full-length human IL-4 protein was used as the immunogen for this Interleukin 4 antibody.

Isotype: IgG2b, kappa

Information d'application

Indications d'application: Optimal dilution of the Interleukin 4 antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store the Interleukin 4 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Détails sur IL-4

Antigène: IL-4 (IL4) (Interleukin 4 (IL4))

Autre désignation: Interleukin 4

Sujet: Interleukin-4 (IL-4), also designated B cell stimulatory factor-1, is a glycosylated cytokine secreted by activated T lymphocytes, basophils and mast cells. The secreted IL-4 protein promotes the growth and differentiation of cells that participate in immune defense by favoring such events as the expansion of the Th2 lineage relative to Th1 cells. These T helper cell subsets are defined by their pattern of cytokine secretion: Th1 cells secrete IL-2, TNF, while Th2 cells secrete IL-4, IL-5 and IL-10. Another key immunological function of IL-4 is to induce immunoglobulin class switching. IL-4 has been shown to induce the production of IgE and enhance IgG4 secretion by B cells, but suppress the production of IgM, IgA, IgG1, IgG2 and IgG3. It has been determined that Stat6 is rapidly tyrosine phosphorylated following stimulation of IL-3 or IL-4, but is not detectably phosphorylated following stimulation with IL-2, IL-12 or erythropoietin.

UniProt: P07750

Pathways: Signalistation JAK/STAT, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Proton Transport, Activated T Cell Proliferation