Keratin 6B anticorps (full length)

N° du produit ABIN7878505

Cet anticorps anti-Keratin 6B Monoclonal Souris (Clone KRT6B-2116) (ABIN7878505) détecte spécifiquement Keratin 6B dans IHC (p). L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour Keratin 6B anticorps (full length) (ABIN7878505)

Antigène: Keratin 6B (KRT6B)

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Keratin 6B est non-conjugé

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: KRT6B-2116

Détail du produit anti-Keratin 6B anticorps

Épitope: full length

Fonction: Cytokeratin 6B Antibody

Purification: Protein G affinity chromatography

Immunogène: Recombinant full-length human KRT6B protein was used as the immunogen for the Cytokeratin 6B antibody.

Isotype: IgG2a, kappa

Information d'application

Indications d'application: Optimal dilution of the Cytokeratin 6B antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store the Cytokeratin 6B antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Détails sur Keratin 6B

Antigène: Keratin 6B (KRT6B)

Autre désignation: Cytokeratin 6B

Sujet: This MAb recognizes a protein of 56 kDa, identified as cytokeratin 6 (CK6). In humans, multiple isoforms of Cytokeratin 6 (6A-6F), encoded by several highly homologous genes, have distinct tissue expression patterns, and Cytokeratin 6A is the dominant form in epithelial tissue. The gene encoding human Cytokeratin 6A maps to chromosome 12q13, and mutations in this gene are linked to several inheritable hair and skin pathologies. Keratins 6 and 16 are expressed in keratinocytes, which are undergoing rapid turnover in the suprabasal region (also known as hyper-proliferation-related keratins). Keratin 6 is found in hair follicles, suprabasal cells of a variety of internal stratified epithelia, in epidermis, in both normal and hyper-proliferative situations. Epidermal injury results in activation of keratinocytes, which express CK6 and CK16. CK6 is strongly expressed in about 75 % of head and neck squamous cell carcinomas. Expression of CK6 is particularly associated with differentiation.

UniProt: P04259