LIG1 anticorps (full length)

N° du produit ABIN7878535

Cet anticorps anti-LIG1 Monoclonal Souris (Clone 1A9) (ABIN7878535) détecte spécifiquement LIG1 dans WB et ELISA. L’anticorps est réactif avec des échantillons de Humain, Rat et Souris.

Aperçu rapide pour LIG1 anticorps (full length) (ABIN7878535)

Antigène: LIG1 (Ligase I, DNA, ATP-Dependent (LIG1))

Reactivité: Humain, Rat, Souris

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp LIG1 est non-conjugé

Application: Western Blotting (WB), ELISA

Clone: 1A9

Détail du produit anti-LIG1 anticorps

Épitope: full length

Fonction: DNA Ligase 1 Antibody / LIG1

Purification: Protein G affinity chromatography

Immunogène: Full-length native cow LIG1 protein was used as the immunogen for the DNA Ligase 1 antibody.

Isotype: IgG1, kappa

Information d'application

Indications d'application: Optimal dilution of the DNA Ligase 1 antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store the DNA Ligase 1 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Détails sur LIG1

Antigène: LIG1 (Ligase I, DNA, ATP-Dependent (LIG1))

Autre désignation: DNA Ligase 1

Sujet: DNA Ligase I maintains the major DNA Ligase activity in proliferating cells by joining Okazaki fragments during lagging strand DNA replication. Human DNA Ligase I also has an essential role in DNA repair pathways, where it catalyzes the formation of phosphodiester bonds between adjacent 5' phosphoryl and 3' hydroxy termini at single breaks in duplex DNA molecules. In addition, DNA Ligase I plays a role in sealing nicks during excision repair. Similar to other DNA ligases, DNA Ligase I is built around a common catalytic core. Increased levels of DNA Ligase I are found in human tumors, as compared to benign tissues, as well as in peripheral blood lymphocytes. Furthermore, DNA Ligase I antisense ODNs syndrome (BS). Individuals with BS either have decreased levels of abnormally thermolabile DNA Ligase I or possess a dimeric form of this enzyme.

UniProt: P18858

Pathways: Telomere Maintenance, Réparation de l'ADN, DNA Replication, Synthesis of DNA